{[4-(tert-butyldimethylsiloxymethyl)-phenyl]-methyl} 2,3,4,6-tetra-O-allyl-β-D-gluco-hexopyranoside | 252060-84-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: {[4-(tert-butyldimethylsiloxymethyl)-phenyl]-methyl} 2,3,4,6-tetra-O-allyl-β-D-gluco-hexopyranoside
• 英文别名: tert-butyl-dimethyl-[[4-[[(2R,3R,4S,5R,6R)-3,4,5-tris(prop-2-enoxy)-6-(prop-2-enoxymethyl)oxan-2-yl]oxymethyl]phenyl]methoxy]silane
• CAS: 252060-84-7
• 化学式: C₃₂H₅₀O₇Si
• 分子量: 574.83
• InChiKey: DHXSKWNKICPEDD-PXPWAULYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.37
• 重原子数：
  40
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  甲基二氯硅烷 、 {[4-(tert-butyldimethylsiloxymethyl)-phenyl]-methyl} 2,3,4,6-tetra-O-allyl-β-D-gluco-hexopyranoside 在 Speiers's catalyst 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 生成 tert-butyl-dimethyl-[[4-[[(2R,3R,4S,5R,6R)-3,4,5-tris[3-[dichloro(methyl)silyl]propoxy]-6-[3-[dichloro(methyl)silyl]propoxymethyl]oxan-2-yl]oxymethyl]phenyl]methoxy]silane
  参考文献：
  名称：

  Synthesis of Selectively Functionalized Carbosilane Dendrimers with a Carbohydrate Core

  摘要：

  [GRAPHICS]First-generation members of a novel family of dendrimers schematically shown above have been synthesized. They display carbohydrate-centered carbosilanes in which one functional group (FG) is discriminated from the others. This will eventually allow their utilization in the synthesis of labeled carbosilanes or as selectively functionalized scaffolds for the preparation of multivalent glycomimetics.

  DOI：

  10.1021/ol9910619
• 作为产物：
  描述：

  4-[(β-D-glucopyranosyloxy)methyl] benzoic acid methyl ester 在 吡啶 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 、 kerosene 为溶剂， 生成 {[4-(tert-butyldimethylsiloxymethyl)-phenyl]-methyl} 2,3,4,6-tetra-O-allyl-β-D-gluco-hexopyranoside
  参考文献：
  名称：

  Synthesis of Selectively Functionalized Carbosilane Dendrimers with a Carbohydrate Core

  摘要：

  [GRAPHICS]First-generation members of a novel family of dendrimers schematically shown above have been synthesized. They display carbohydrate-centered carbosilanes in which one functional group (FG) is discriminated from the others. This will eventually allow their utilization in the synthesis of labeled carbosilanes or as selectively functionalized scaffolds for the preparation of multivalent glycomimetics.

  DOI：

  10.1021/ol9910619

文献信息

• Synthesis of Selectively Functionalized Carbosilane Dendrimers with a Carbohydrate Core
  作者：Mike M. K. Boysen、Thisbe K. Lindhorst

  DOI：10.1021/ol9910619

  日期：1999.12.1

  [GRAPHICS]First-generation members of a novel family of dendrimers schematically shown above have been synthesized. They display carbohydrate-centered carbosilanes in which one functional group (FG) is discriminated from the others. This will eventually allow their utilization in the synthesis of labeled carbosilanes or as selectively functionalized scaffolds for the preparation of multivalent glycomimetics.