7-(nitromethyl)-1,4-dioxaspiro[4.5]decane | 29897-29-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-(nitromethyl)-1,4-dioxaspiro[4.5]decane
• 英文别名: spiro<(3-nitromethylcyclohexane)-1,2'-dioxolane>；3-Nitromethyl-cyclohexanon-aethylenketal；7-(Nitromethyl)-1,4-dioxaspiro[4.5]decane
• CAS: 29897-29-8
• 化学式: C₉H₁₅NO₄
• 分子量: 201.222
• InChiKey: ABJZYRJMWWASNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-(nitromethyl)-1,4-dioxaspiro[4.5]decane 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以71%的产率得到spiro<(3-aminomethylcyclohexane)-1,2'-dioxolane>
  参考文献：
  名称：

  亚二氢吲哚，吲哚和吲哚，二十一吗啉相关化合物的吲哚方法

  摘要：

  吲哚15的亚硝酸脱氨基用作制备吗啡类似物1b的新策略中的关键反应。

  DOI：

  10.1016/s0040-4039(00)85512-4
• 作为产物：
  描述：

  2-环己烯-1-酮 在 四丁基氟化铵 、 silica gel 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 7-(nitromethyl)-1,4-dioxaspiro[4.5]decane
  参考文献：
  名称：

  亚二氢吲哚，吲哚和吲哚，二十一吗啉相关化合物的吲哚方法

  摘要：

  吲哚15的亚硝酸脱氨基用作制备吗啡类似物1b的新策略中的关键反应。

  DOI：

  10.1016/s0040-4039(00)85512-4

文献信息

• An Acidic Layered Clay Is Combined with A Basic Layered Clay for One-Pot Sequential Reactions
  作者：Ken Motokura、Noriaki Fujita、Kohsuke Mori、Tomoo Mizugaki、Kohki Ebitani、Kiyotomi Kaneda

  DOI：10.1021/ja052386p

  日期：2005.7.13

  A Ti4+-exchanged montmorillonite (Ti4+-mont) and a hydrotalcite (HT) are strong solid Brønsted acid and base, and these two clay catalysts could be used in a single reactor without neutralization of active sites. Because the Ti4+-mont have active acid site in the narrow interlayers, the base sites of large HT particles show no interaction with the acid sites. A variety of acid and base reactions, such as esterification, acetalization, deacetalization, aldol reaction, Michael reaction, and epoxidation, proceeded using both the Ti4+-mont and the HT in a single reactor.
• TRPV4 ANTAGONISTS
  申请人：GlaxoSmithKline Intellectual Property (No. 2) Limited

  公开号：EP2720697B1

  公开（公告）日：2016-07-20
• US8927585B2
  申请人：——

  公开号：US8927585B2

  公开（公告）日：2015-01-06
• [EN] TRPV4 ANTAGONISTS<br/>[FR] ANTAGONISTES DE TRPV4
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2012174340A1

  公开（公告）日：2012-12-20

  The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists. The TRPV4 antagonist may be administered alone or in conjunction with one or more other therapeutic agents, ego agents being selected from the group consisting of endothelin receptor antagonists, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists, vasopeptidase inhibitors, vasopressin receptor modulators, diuretics, digoxin, beta blocker, aldosterone antagonists, iontropes, NSAIDS, nitric oxide donors, calcium channel modulators, muscarinic antagonists, steroidal anti-inflammatory drugs, bronchodilators, anti-histamines, leukotriene antagonist, HMG-CoA reductase inhibitors, dual non-selective padrenoceptor and u1 -adrenoceptor antagonists, type-5 phosphodiesterase inhibitors, and renin inhibitors.
• Methylene-indolines, indolenines and indoleniniums, XXI an indolenine approach to morphine related compounds
  作者：J.Y. Laronze、J. Laronze、D. Patigny、J. Lévy

  DOI：10.1016/s0040-4039(00)85512-4

  日期：1986.1

  Nitrous acid deamination of indolenine 15 was used as the key reaction in a new strategy for preparing the morphine analogue 1b.

  吲哚15的亚硝酸脱氨基用作制备吗啡类似物1b的新策略中的关键反应。