(+/-)-3r,4c-dihydroxy-3,5t-diphenyl-dihydro-furan-2-one | 6267-04-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (+/-)-3r,4c-dihydroxy-3,5t-diphenyl-dihydro-furan-2-one
• 英文别名: (+/-)-3r,4c-Dihydroxy-3,5t-diphenyl-dihydro-furan-2-on；(3R,4R,5R)-3,4-dihydroxy-3,5-diphenyloxolan-2-one
• CAS: 6267-04-5
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: RZTWOKJTGPVIQG-IIAWOOMASA-N

物化性质

• 沸点：
  469.4±25.0 °C(Predicted)
• 密度：
  1.371±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (+/-)-3r,4c-dihydroxy-3,5t-diphenyl-dihydro-furan-2-one 、 乙酰氯 生成 (+/-)-3r,4c-diacetoxy-3,5t-diphenyl-dihydro-furan-2-one
  参考文献：
  名称：

  Intravenous tenoxicam reduces uterine cramps after Cesarean delivery

  摘要：

  Purpose: Postpartum uterine contraction pain is a common phenomenon after Cesarean delivery. We investigated the effectiveness of tenoxicam in reducing uterine contraction pain,Methods: We enrolled 120 consecutive non-breastfeeding women who were scheduled for elective Cesarean delivery. After the administration of spinal anesthesia with bupivacaine and intrathecal morphine 0.15 mg injection, the patients were randomly divided into two groups, Group I received placebo (normal saline) iv injection, and Group II received tenoxicam 40 mg iv injection after clamping the umbilical cord. Verbal analogue scale of wound pain and uterine contraction pain were recorded at two, four, eight, 16, and 24 hr after Cesarean delivery.Results: There was no significant difference in wound pain scores between the two groups (all scores : 3). However, the tenoxicam group had significant lower uterine contraction pain scores and required less supplemental meperidine medication than did the placebo group (8.5% vs 41.4%, P < 0.05). The incidences of nausea or vomiting, pruritus, and bleeding were not significantly different between groups.Conclusion: Intravenous tenoxicam 40 mg significantly reduced the intensity of uterine cramps in patients undergoing Cesarean delivery without increasing side effects.

  DOI：

  10.1007/bf03017327
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 potassium permanganate 、 magnesium sulfate 、 丙酮 作用下， 生成 (+/-)-3r,4c-dihydroxy-3,5t-diphenyl-dihydro-furan-2-one
  参考文献：
  名称：

  Intravenous tenoxicam reduces uterine cramps after Cesarean delivery

  摘要：

  Purpose: Postpartum uterine contraction pain is a common phenomenon after Cesarean delivery. We investigated the effectiveness of tenoxicam in reducing uterine contraction pain,Methods: We enrolled 120 consecutive non-breastfeeding women who were scheduled for elective Cesarean delivery. After the administration of spinal anesthesia with bupivacaine and intrathecal morphine 0.15 mg injection, the patients were randomly divided into two groups, Group I received placebo (normal saline) iv injection, and Group II received tenoxicam 40 mg iv injection after clamping the umbilical cord. Verbal analogue scale of wound pain and uterine contraction pain were recorded at two, four, eight, 16, and 24 hr after Cesarean delivery.Results: There was no significant difference in wound pain scores between the two groups (all scores : 3). However, the tenoxicam group had significant lower uterine contraction pain scores and required less supplemental meperidine medication than did the placebo group (8.5% vs 41.4%, P < 0.05). The incidences of nausea or vomiting, pruritus, and bleeding were not significantly different between groups.Conclusion: Intravenous tenoxicam 40 mg significantly reduced the intensity of uterine cramps in patients undergoing Cesarean delivery without increasing side effects.

  DOI：

  10.1007/bf03017327

文献信息

• Intravenous tenoxicam reduces uterine cramps after Cesarean delivery
  作者：Yu -Chen Huang、Shen -Kou Tsai、Chi -Hsiang Huang、Mao -Hsien Wang、Pei -Lin Lin、Li -Kuei Chen、Chen -Jung Lin、Wei -Zen Sun

  DOI：10.1007/bf03017327

  日期：2002.4

  Purpose: Postpartum uterine contraction pain is a common phenomenon after Cesarean delivery. We investigated the effectiveness of tenoxicam in reducing uterine contraction pain,Methods: We enrolled 120 consecutive non-breastfeeding women who were scheduled for elective Cesarean delivery. After the administration of spinal anesthesia with bupivacaine and intrathecal morphine 0.15 mg injection, the patients were randomly divided into two groups, Group I received placebo (normal saline) iv injection, and Group II received tenoxicam 40 mg iv injection after clamping the umbilical cord. Verbal analogue scale of wound pain and uterine contraction pain were recorded at two, four, eight, 16, and 24 hr after Cesarean delivery.Results: There was no significant difference in wound pain scores between the two groups (all scores : 3). However, the tenoxicam group had significant lower uterine contraction pain scores and required less supplemental meperidine medication than did the placebo group (8.5% vs 41.4%, P < 0.05). The incidences of nausea or vomiting, pruritus, and bleeding were not significantly different between groups.Conclusion: Intravenous tenoxicam 40 mg significantly reduced the intensity of uterine cramps in patients undergoing Cesarean delivery without increasing side effects.