4t-(4-hydroxy-3-methyl-phenyl)-but-3-en-2-one | 7733-52-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 4t-(4-hydroxy-3-methyl-phenyl)-but-3-en-2-one
• 英文别名: 4t-(4-Hydroxy-3-methyl-phenyl)-but-3-en-2-on；(E)-4-(4-hydroxy-3-methylphenyl)but-3-en-2-one
• CAS: 7733-52-0
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: YRZSAMYLGJKNAK-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4t-(4-hydroxy-3-methyl-phenyl)-but-3-en-2-one 生成 4t-(4-hydroxy-3-methyl-phenyl)-but-3-en-2-one semicarbazone
  参考文献：
  名称：

  Kin, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1943, vol. 63, p. 376,381

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-4-羟基苯甲醛 、 丙酮 在 sodium hydroxide 作用下， 生成 4t-(4-hydroxy-3-methyl-phenyl)-but-3-en-2-one
  参考文献：
  名称：

  Kin, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1943, vol. 63, p. 376,381

  摘要：

  DOI：

文献信息

• Gallium(III) Chloride Catalyzed Stereoselective Synthesis of <i>E</i>-Configured α,β-Unsaturated Ketones
  作者：J. Yadav、B. Reddy、Manoj Gupta、Uttam Dash、Sushil Pandey

  DOI：10.1055/s-2007-970760

  日期：2007.3

  A simple and highly stereoselective method has been developed for the synthesis of E-configured α,β-unsaturated ketones using gallium(III) chloride as a novel catalyst. This new procedure offers significant advantages such as high conversions, short reaction times and enhanced E-selectivity together with mild reaction conditions.

  已经开发了一种简单且高度立体选择性的方法，用于使用氯化镓 (III) 作为新型催化剂合成 E 构型的 α,β-不饱和酮。这种新方法具有显着的优势，例如高转化率、短反应时间和增强的 E 选择性以及温和的反应条件。
• ANTHRANILSÄUREAMIDE UND DEREN DERIVATE ALS KOSMETISCHE UND PHARMAZEUTISCHE WIRKSTOFFE
  申请人：Symrise AG

  公开号：EP1567143B1

  公开（公告）日：2013-08-14
• HYDROSOLUBLE [6)O-ALPHA-D-GLCP-(1->]N-6-O-BETA-D-GLCP-(1->-PHENOLIC DERIVATIVES WITH DERMOCOSMETIC, NUTRITIONAL AND THERAPEUTIC APPLICATIONS, AND COMPOSITIONS CONTAINING SAID WATER SOLUBLE COMPOUNDS
  申请人：Auriol Daniel

  公开号：US20110256115A1

  公开（公告）日：2011-10-20

  The invention relates to [6)O-α-D-Glcp-(1→] n -6-O-β-D-Glcp-(1→-phenolic derivatives. These [6)O-α-D-Glcp-(1→] n -6-O-β-D-Glcp-(1→-phenolic derivatives of selected phenolics are new, have a solubility in water higher than that of their parent O-β-D-Glcp-(1→-phenolic derivatives and have useful applications in cosmetic, nutrition and pharmaceutical compositions, such as treating or preventing oxidative stress, a cancer, a cardiovascular disease, a bacterial infection, a viral infection, a fungal infection, a UV-induced erythema, an allergy, a metabolism disorder, diabetes, an obesity, a hormonal disorder, a bone disease, a pain, a brain disease, a mouth or teeth disease, an inflammatory or immune disorder.
• ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
  申请人：Cognition Therapeutics, Inc.

  公开号：US20170144970A1

  公开（公告）日：2017-05-25

  Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.
• COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE
  申请人：Chromocell Corporation

  公开号：US20180002306A1

  公开（公告）日：2018-01-04

  The present disclosure provides edible compositions comprising a flavor-grade sweet taste modulator or a combination of flavor-grade sweet taste modulators or a flavor-grade bitter taste blocker or a combination of flavor-grade bitter taste blockers of the present disclosure, food products comprising such edible compositions and methods of preparing such food products. The present disclosure also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste or blocking a bitter taste in a food product.