1-Hydroxymethyl-3-pentadecylcyclopentan | 65148-98-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Hydroxymethyl-3-pentadecylcyclopentan
• 英文别名: (3-pentadecylcyclopentyl)methanol
• CAS: 65148-98-3
• 化学式: C₂₁H₄₂O
• 分子量: 310.564
• InChiKey: QLRNWVLWPOOERJ-UHFFFAOYSA-N

物化性质

• 沸点：
  371.3±10.0 °C(Predicted)
• 密度：
  0.863±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.88
• 重原子数：
  22.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1-Hydroxymethyl-3-pentadecylcyclopentan 在 platinum(IV) oxide 吡啶 、 氢气 作用下， 以 乙醇 为溶剂， 生成 (3-Pentadecylcyclopentyl)methyl dihydrogen phosphate
  参考文献：
  名称：

  Hypotensive phospholipids. Some stable analogs of Darmstoff

  摘要：

  2-Pentadecyl-4-hydroxymethyl-1,3-dioxolane monosodium phosphate (1) has been shown to exhibit bradycardia and hypotension in rats. It is, however, unstable in aqueous solution. In this study, the stable analogues of 1, 2-pentadecyl-5-hydroxymethyltetrahydrofuran monosodium phosphate (7), and 1-hydroxymethyl-3-pentadecylcyclopentane monosodium phosphate (17) were prepared. These substances exhibited cardiovascular effects similar both qualitively and quantitatively to those elicited by 1 and were stable in solution for about 24 and at least 72 h, respectively.

  DOI：

  10.1021/jm00201a001
• 作为产物：
  描述：

  4-十五烷基苯酚 在 rhodium on alumina chromium(VI) oxide 、 lithium aluminium tetrahydride 、 磺酰氯 、 硫酸 、 氢气 、 sodium 、 苯甲醇 作用下， 以 四氯化碳 、 乙醚 、 乙醇 、 丙酮 为溶剂， 生成 1-Hydroxymethyl-3-pentadecylcyclopentan
  参考文献：
  名称：

  Hypotensive phospholipids. Some stable analogs of Darmstoff

  摘要：

  2-Pentadecyl-4-hydroxymethyl-1,3-dioxolane monosodium phosphate (1) has been shown to exhibit bradycardia and hypotension in rats. It is, however, unstable in aqueous solution. In this study, the stable analogues of 1, 2-pentadecyl-5-hydroxymethyltetrahydrofuran monosodium phosphate (7), and 1-hydroxymethyl-3-pentadecylcyclopentane monosodium phosphate (17) were prepared. These substances exhibited cardiovascular effects similar both qualitively and quantitatively to those elicited by 1 and were stable in solution for about 24 and at least 72 h, respectively.

  DOI：

  10.1021/jm00201a001

文献信息

• Hypotensive phospholipids. Some stable analogs of Darmstoff
  作者：Alfred N. Milbert、Robert A. Wiley

  DOI：10.1021/jm00201a001

  日期：1978.3

  2-Pentadecyl-4-hydroxymethyl-1,3-dioxolane monosodium phosphate (1) has been shown to exhibit bradycardia and hypotension in rats. It is, however, unstable in aqueous solution. In this study, the stable analogues of 1, 2-pentadecyl-5-hydroxymethyltetrahydrofuran monosodium phosphate (7), and 1-hydroxymethyl-3-pentadecylcyclopentane monosodium phosphate (17) were prepared. These substances exhibited cardiovascular effects similar both qualitively and quantitatively to those elicited by 1 and were stable in solution for about 24 and at least 72 h, respectively.