4-十五烷基苯酚 | 5394-76-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 4-十五烷基苯酚
• 英文名称: 4-pentadecylphenol
• 英文别名: p-pentadecylphenol
• CAS: 5394-76-3
• 化学式: C₂₁H₃₆O
• 分子量: 304.516
• InChiKey: MSTWJNRTDPVXOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2907199090

反应信息

• 作为反应物：
  描述：

  4-十五烷基苯酚 在 rhodium on alumina chromium(VI) oxide 、 lithium aluminium tetrahydride 、 磺酰氯 、 硫酸 、 氢气 、 sodium 、 苯甲醇 作用下， 以 四氯化碳 、 乙醚 、 乙醇 、 丙酮 为溶剂， 生成 1-Hydroxymethyl-3-pentadecylcyclopentan
  参考文献：
  名称：

  Hypotensive phospholipids. Some stable analogs of Darmstoff

  摘要：

  2-Pentadecyl-4-hydroxymethyl-1,3-dioxolane monosodium phosphate (1) has been shown to exhibit bradycardia and hypotension in rats. It is, however, unstable in aqueous solution. In this study, the stable analogues of 1, 2-pentadecyl-5-hydroxymethyltetrahydrofuran monosodium phosphate (7), and 1-hydroxymethyl-3-pentadecylcyclopentane monosodium phosphate (17) were prepared. These substances exhibited cardiovascular effects similar both qualitively and quantitatively to those elicited by 1 and were stable in solution for about 24 and at least 72 h, respectively.

  DOI：

  10.1021/jm00201a001
• 作为产物：
  描述：

  1-(4-hydroxy-phenyl)-pentadecan-1-one 在 盐酸 、 amalgamated zinc 作用下， 生成 4-十五烷基苯酚
  参考文献：
  名称：

  Synthesis of the Mono- and Dihydric Pentadecylphenols Related to Poison Ivy “Urushiol”

  摘要：

  DOI：

  10.1021/ja01597a060

文献信息

• INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES
  申请人：Jung Young Sik

  公开号：US20140114068A1

  公开（公告）日：2014-04-24

  Disclosed are novel indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

  揭示了新颖的茚酮衍生物，其药用盐或对映体，以及其制备方法和作为活性成分的用于预防或治疗病毒性疾病的药物组合物。这些茚酮衍生物对包括柯萨奇病毒、肠道病毒、回声病毒、脊髓灰质炎病毒和鼻病毒在内的小RNA病毒具有出色的抑制活性，并且具有低细胞毒性，因此它们可用作预防或治疗包括小儿麻痹症、瘫痪、急性出血性结膜炎、病毒性脑膜炎、手足口病、水疱病、甲型肝炎、肌炎、心肌炎、胰腺炎、糖尿病、流行性肌痛、脑炎、流感、手足口病、哮喘、慢性阻塞性肺病、肺炎、鼻窦炎或中耳炎等病毒性疾病的药物组合物的活性成分。
• Palladium-catalyzed Tsuji–Trost-type reaction of benzofuran-2-ylmethyl acetates with nucleophiles
  作者：Antonio Arcadi、Giancarlo Fabrizi、Andrea Fochetti、Francesca Ghirga、Antonella Goggiamani、Antonia Iazzetti、Federico Marrone、Giulia Mazzoccanti、Andrea Serraiocco

  DOI：10.1039/d0ra09601f

  日期：——

  palladium-catalyzed benzylic-like nucleophilic substitution of benzofuran-2-ylmethyl acetate with N, S, O and C soft nucleophiles has been investigated. The success of the reaction is dramatically influenced by the choice of catalytic system: with nitrogen based nucleophiles the reaction works well with Pd2(dba)3/dppf, while with sulfur, oxygen and carbo-nucleophiles [Pd(η3-C3H5)Cl]2/XPhos is more efficient

  研究了钯催化的苯并呋喃-2-基甲基乙酸酯与 N、S、O 和 C 软亲核试剂的类苄基亲核取代反应。反应的成功很大程度上取决于催化体系的选择：对于氮基亲核试剂，反应与 Pd2(dba)3/dppf 反应良好，而对于硫、氧和碳亲核试剂 [Pd(η3-C3H5)Cl] 2/XPhos 效率更高。区域化学结果表明，亲核取代仅发生在 η3-(苯并呋喃基)甲基配合物的苄位上。高至优异的产率和实验程序的简单性使该方案成为制备 2-取代苯并[b]呋喃的通用合成工具。
• CYCLOSILOXANE-SUBSTITUTED POLYSILOXANE COMPOUNDS, COMPOSITIONS CONTAINING THE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Wray Daniel X.

  公开号：US20120064022A1

  公开（公告）日：2012-03-15

  Provided herein are cyclosiloxane-substituted polysiloxane compounds, compositions that include the polysiloxane compounds, and methods for preparation and use of the polysiloxane compounds. Provided are mechanical lubricant compositions, hydraulic fluid compositions, anti-foam compositions, water repellant agent compositions, release agent compositions, personal care compositions, cosmetic compositions, household care compositions and drug delivery compositions that include one or more of the cyclosiloxane-substituted polysiloxane compounds provided herein.

  本文提供了含有环硅氧烷取代聚硅氧烷化合物的化合物、包括这些聚硅氧烷化合物的组合物，以及这些聚硅氧烷化合物的制备和使用方法。提供了包括本文提供的一种或多种环硅氧烷取代聚硅氧烷化合物的机械润滑剂组合物、液压液组合物、抗泡沫组合物、防水剂组合物、脱模剂组合物、个人护理组合物、化妆品组合物、家庭护理组合物和药物传递组合物。
• [EN] PROCESS FOR PREPARING A CROSS LINKING CATALYST FROM CASHEW NUT SHELL LIQUID<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN CATALYSEUR DE RÉTICULATION À PARTIR DE BAUME DE CAJOU
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2013084248A1

  公开（公告）日：2013-06-13

  The present invention discloses synthesis of sulfonated, alkylated/arylated 3-pentadecyl phenols, (cross linking catalysts) starting from 3-pentadecyl phenol obtained from Cashew Nut Shell Liquid (CNSL).

  本发明公开了从腰果壳油(CNSL)中获得的3-十五烷基酚合成磺化、烷基化/芳基化3-十五烷基酚(交联催化剂)的方法。
• Overbased sulfurized alkaline earth metal phenates and process for preparing same
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0486893A1

  公开（公告）日：1992-05-27

  Overbased sulfurized alkaline earth metal phenates which are oil soluble, excellent in detergency dispersancy and have high base value, and an effective process for production of said overbased sulfurized alkaline earth metal phenates under conditions providing less sludge and less raw material recovery, and further a lubricating oil additives containing said overbased sulfurized alkaline earth metal phenates as a main ingredient and a lubricating oil composition which comprises said lubricating oil additive compounded in a lubricating oil are disclosed. Since the resulting overbased sulfurized alkaline earth metal phenates have high base value and excellent oil-solubility, they can be effectively utilized as lubricating oil additives.

  过基硫化碱土金属酚酸盐是油溶性的，具有优异的清洁分散性和高碱值，并且提供了在条件下生产所述过基硫化碱土金属酚酸盐的有效工艺，该条件下可减少泥渣和原料回收，进一步揭示了含有所述过基硫化碱土金属酚酸盐作为主要成分的润滑油添加剂和润滑油组合物，该润滑油添加剂混合在润滑油中。由于所得的过基硫化碱土金属酚酸盐具有高碱值和优异的油溶性，因此它们可以有效地用作润滑油添加剂。