Elemental Chalcogen (Se, S) in PEG-400 to the Synthesis of Seleno- and Thioflavones from 2-Chlorophenyl Ethynyl Ketone and Nucleophilic Species of Chalcogen
的单釜,过渡金属-自由,多米诺迈克尔/ S Ñ普遍适用性的Ar协议已经通过使用硝基甲烷和设计用于多官能萘的区域选择性合成邻-haloaryl ynones。硝基甲烷作为一种碳碳负离子源的使用,并被引入到各种炔酮中,最终以芳族硝基取代基的形式出现。该多米诺法在多环生物碱马卡平的全合成中的应用证明了该方法的有效性。在概念上是简单的方法来影响ynones显示广泛的底物范围和官能团耐受性,并已与被取代的硝基甲烷实现的区域选择性,多功能benzoannulation以及与脂环ö-单倍体。
A novel photoredox catalysis for multiple functionalization of two different types of unactivatedalkenes in a single operation was reported through a conceptually new mode of annulation-alkynyl migration. A wide array of cyclopentane carboxylates were synthesized in a highly selective and functional-group-compatible manner via C-centered radical induced cascade 5-exo-trig/5-exo-dig bicyclization and
Silica-supported zinc bromide (ZnBr2/SiO2) is an efficient heterogeneous catalyst for the rapidsynthesis of ynones by cross-coupling of acid chlorides with terminal alkynes in good to excellentyieldsundersolvent-freeconditions at roomtemperature.
Polystyrene-Supported Zinc Bromide-Ethylenediamine Complex as a Reusable and Highly Efficient Heterogeneous Catalyst for the Synthesis of α,β-Acetylenic Ketones
A polystyrene-supported zinc bromide-ethylenediamine complex was shown to be useful as a recyclable heterogeneouscatalyst for the rapid and efficient synthesis of α,β-acetylenic ketones in good-to-excellent yields by cross-coupling of acid chlorides with terminal alkynes. The catalyst is easily prepared, stable, reusable, and efficient under the reaction conditions. heterogeneous catalysis - cross-coupling
A one-pot coupling–addition–cyclocondensation sequence (CACS) to 2-substituted 3-acylpyrroles initiated by a copper-free alkynylation
作者:Jan Nordmann、Thomas J. J. Müller
DOI:10.1039/c3ob41269e
日期:——
A novel three-component synthesis of 2-substituted 3-acylpyrroles can be initiated by a copper-free Pd-catalyzed alkynylation in a one-pot fashion. The reaction sequence proceeds under mild reaction conditions and in moderate to good yields with a broad scope of diversity.
Efficient Consecutive Four-Component Synthesis of 5-Acylpyrid-2-ones Initiated by Copper-Free Alkynylation
作者:Jan Nordmann、Natascha Breuer、Thomas J. J. Müller
DOI:10.1002/ejoc.201300235
日期:2013.7
A one-pot, consecutive, four-componentsynthesis of 5-acylpyrid-2-onesinitiated by Pd/cataCXium® ABn catalysis proceeds under mild reaction conditions and in good yields, with a broad scope of three points of diversity. This sequence is superior to the initially proposed Pd/Cu-catalyzed version because all four components can be employed in close to stoichiometric amounts.
由 Pd/cataCXium® ABn 催化引发的 5-acylpyrid-2-one 的一锅、连续、四组分合成在温和的反应条件下以良好的收率进行,具有广泛的三点多样性。该序列优于最初提出的 Pd/Cu 催化版本,因为所有四种组分都可以以接近化学计量的量使用。