2,2-Dimethyl-4-pentyloxymethyl-1,3-dioxolane | 140468-06-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-Dimethyl-4-pentyloxymethyl-1,3-dioxolane
• 英文别名: 2,2-dimethyl-4-(pentoxymethyl)-1,3-dioxolane
• CAS: 140468-06-0
• 化学式: C₁₁H₂₂O₃
• 分子量: 202.294
• InChiKey: KPSFWIIFWIAGHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-4-pentyloxymethyl-1,3-dioxolane 在 硫酸 作用下， 以 甲醇 为溶剂， 反应 1.5h， 生成 3-戊基氧基丙烷-1,2-二醇
  参考文献：
  名称：

  Analogs of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor

  摘要：

  A series of aryl phosphoglyceride (3, 19-6 1) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in which the position of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected compounds were also evaluated for their ability to displace [H-3]PAF from its receptor on rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in both the mouse and rabbit, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Compound 105 (CL 184005) has been selected to undergo further development as a potential therapeutic agent for the treatment of septic shock in man.

  DOI：

  10.1021/jm00087a023
• 作为产物：
  描述：

  甲苯-4-磺酸戊酯 、 丙酮缩甘油 在 sodium hydride 、 sodium iodide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 2,2-Dimethyl-4-pentyloxymethyl-1,3-dioxolane
  参考文献：
  名称：

  Analogs of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor

  摘要：

  A series of aryl phosphoglyceride (3, 19-6 1) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in which the position of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected compounds were also evaluated for their ability to displace [H-3]PAF from its receptor on rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in both the mouse and rabbit, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Compound 105 (CL 184005) has been selected to undergo further development as a potential therapeutic agent for the treatment of septic shock in man.

  DOI：

  10.1021/jm00087a023

文献信息

• Process for producing glyceryl ether
  申请人：Kao Corporation

  公开号：US06437196B1

  公开（公告）日：2002-08-20

  A process for producing a glyceryl ether which contains a markedly small amount of organohalogen compounds and therefore can be used even for cosmetics and body detergents. The process comprises reacting an alcohol with an &agr;-epihalohydrin in the presence of an acid catalyst, subjecting the reaction mixture to ring closure to convert it into the corresponding glycidyl ether and then hydrolyzing the glycidyl ether, wherein: (a) the hydrolysis is effected at 140 to 230° C. in the presence of a salt formed from a strongly basic compound and a weakly acidic compound, or (b) the reaction mixture after the hydrolysis is heated at 100 to 230° C. in the presence of a salt formed from a strongly basic compound and a weakly acidic compound.

  一种生产甘油醚的方法，其中含有明显少量的有机卤化物，因此可用于化妆品和身体清洁剂。该方法包括在酸催化剂的存在下，将醇与α-环氧卤水化物反应，将反应混合物经环闭合反应转化为相应的环氧甘油醚，然后水解环氧甘油醚，其中：(a)水解在强碱性化合物和弱酸性化合物形成的盐的存在下，在140至230°C下进行，或者(b)水解后的反应混合物在强碱性化合物和弱酸性化合物形成的盐的存在下，在100至230°C下加热。
• PROCESS FOR PRODUCING GLYCERYL ETHER
  申请人：Kao Corporation

  公开号：EP1066234B1

  公开（公告）日：2003-06-11
• US6437196B1
  申请人：——

  公开号：US6437196B1

  公开（公告）日：2002-08-20
• Analogs of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor
  作者：A. Wissner、M. L. Carroll、K. E. Green、S. S. Kerwar、W. C. Pickett、R. E. Schaub、L. W. Torley、S. Wrenn、C. A. Kohler

  DOI：10.1021/jm00087a023

  日期：1992.5

  A series of aryl phosphoglyceride (3, 19-6 1) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in which the position of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected compounds were also evaluated for their ability to displace [H-3]PAF from its receptor on rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in both the mouse and rabbit, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Compound 105 (CL 184005) has been selected to undergo further development as a potential therapeutic agent for the treatment of septic shock in man.