2-amino-1-(3-hydroxyphenyl)ethyl ketone | 90005-54-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-amino-1-(3-hydroxyphenyl)ethyl ketone
• 英文别名: 3-Hydroxy-ω-aminoacetophenone；2-amino-1-(3-hydroxy-phenyl)-ethanone；2-Amino-1-(3-hydroxy-phenyl)-aethanon；3-Hydroxy-α-amino-acetophenon；3-Glycyl-phenol；2-Amino-1-(3-hydroxyphenyl)ethanone
• CAS: 90005-54-2
• 化学式: C₈H₉NO₂
• 分子量: 151.165
• InChiKey: SCHLZTPPFPHHPY-UHFFFAOYSA-N

物化性质

• 熔点：
  217–220°C

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-1-(3-hydroxyphenyl)ethyl ketone 在 palladium on activated charcoal 、 乙醇 、 铂 作用下， 生成 美他特罗
  参考文献：
  名称：

  D'Amico et al., Chimica e l'Industria (Milan, Italy), 1956, vol. 38, p. 93,98

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-3-羟基乙酰苯 在 platinum on activated charcoal 盐酸 、 sodium azide 、 氢气 、 甲基三辛基氯化铵 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 2-amino-1-(3-hydroxyphenyl)ethyl ketone
  参考文献：
  名称：

  7-Alkyl- and 7-Cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines—potent inhibitors of the tyrosine kinase c-Src

  摘要：

  7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from alpha -bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60(c-Src) with good specificity towards other tyrosine kinases (EGF-R, v-Abl). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00079-8

文献信息

• AMIDE COMPOUND, PREPARATION METHOD AND USES THEREOF
  申请人：Yu Zhenpeng

  公开号：US20140128463A1

  公开（公告）日：2014-05-08

  Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 4 , R 5 , Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

  本公开涉及酰胺化合物、其制备方法和用途，具体地说，是由式I表示的化合物或药学上可接受的盐，其中R1、R2、R3、R4、R5、Q、X和n的定义如描述中所述。还公开了一种制备式I化合物的方法，含有该化合物的组合物，以及在制备用于调节血脂和/或预防胆结石的药物中使用它的用途。本发明公开的式I化合物在体外具有稳定性，在制药有机溶剂中具有良好的溶解性，并在动物体内具有良好的生物利用度。
• LIGHT FILTERS COMPRISING A NATURALLY OCCURRING CHROMOPHORE AND DERIVATIVES THEREOF
  申请人：BENZ Patrick H.

  公开号：US20110166381A1

  公开（公告）日：2011-07-07

  A composition comprising a polymer backbone and at least one side group, wherein the side group comprises a benzene ring-based chromophore comprising a ketone at the 1-position, a substituted or unsubstituted amino group at the 2-position, and an oxygen atom at the 3-position of the benzene ring. The chromophore is a kynurenine-based compound. Methods of making and using the composition are also provided. The composition can be used in an ophthalmic lens or device for protecting the retina by blocking UV rays and filtering violet rays.

  一种组成物，包括聚合物骨架和至少一个侧基团，其中侧基团包括一个苯环为基础的色团，包括1-位置的酮基，2-位置的取代或未取代氨基和苯环的3-位置的氧原子。该色团是基于骈氨酸的化合物。还提供了制备和使用该组成物的方法。该组成物可用于眼科镜片或设备中，通过阻挡紫外线和过滤紫外线，保护视网膜。
• Light filters comprising a naturally occurring chromophore and derivates thereof
  申请人：Benz Research and Development Corporation

  公开号：EP2535747A2

  公开（公告）日：2012-12-19

  A composition comprising a polymer backbone and at least one side group, wherein the side group comprises a benzene ring-based chromophore comprising a ketone at the 1-position, a substituted or unsubstituted amino group at the 2-position, and an oxygen atom at the 3-position of the benzene ring having the following formula: wherein R1 is H, an alkyl group, or comprises an amino acid moiety or derivative thereof; R2 and R3 are individually H, alkyl, or any moiety with a vinyl functionality; R4 is an alkyl group, any moiety with a vinyl functionality, a counterpart alkylβne group, or a sugar moiety; and X is an optional electron-donating group linked to the benzene ring at the 4, 5, or 6 position. The chromophore is a kynurenine-based compound. Methods of making and using the composition are also provided. The composition can be used in an ophthalmic lens or device for protecting the retina by blocking UV rays and filtering violet rays.

  一种由聚合物骨架和至少一个侧基组成的组合物，其中侧基包括基于苯环的发色团，该发色团在苯环的 1 位上包括一个酮，在 2 位上包括一个取代或未取代的氨基，在 3 位上包括一个氧原子，该发色团具有下式：其中 R1 是 H、烷基或包含氨基酸分子或其衍生物；R2 和 R3 分别是 H、烷基或任何具有乙烯基官能团的分子；R4 是烷基、任何具有乙烯基官能团的分子、对应的烷基β炔基或糖分子；X 是在 4、5 或 6 位与苯环相连的任选电子供体。发色团是一种犬尿氨酸基化合物。还提供了制造和使用该组合物的方法。该组合物可用于眼科镜片或装置中，通过阻挡紫外线和过滤紫外线来保护视网膜。
• Radio frequency electro-thrombectomy device
  申请人：The Hong Kong University of Science and Technology

  公开号：US10912608B2

  公开（公告）日：2021-02-09

  A device is designed to remove blockages in a lumen such as a thrombus, blood clot, or embolus. The device comprises a manipulating wire and a structure that can conduct electrical current to a lumen blockage. The electrical current is preferably in radio frequency (RF). The RF electric current in the blockage can excite the contents such as proteins of the blockage, so that cross-linking density and interfacial adsorption of the entire blockage is enhanced. The enhanced cross-linking density can result in increased fracture resistance of the blockage such that fracture of the blockage during the removal process is unlikely. The enhanced interfacial adsorption results in increased interfacial fracture resistance between the device and blockage so that the blockage can be securely captured during the removal process without using radially applied force.

  一种装置用于清除管腔中的堵塞物，如血栓、血块或栓子。该装置包括一根操作线和一个可将电流传导至管腔堵塞物的结构。电流最好是射频（RF）。堵塞物中的射频电流可激发堵塞物中的蛋白质等成分，从而提高整个堵塞物的交联密度和界面吸附力。增强的交联密度可提高堵塞物的抗断裂能力，从而使堵塞物在移除过程中不太可能断裂。增强的界面吸附力可提高装置与堵塞物之间的界面抗断裂能力，从而在移除过程中无需使用径向外力即可牢牢抓住堵塞物。
• US2786871
  申请人：——

  公开号：——

  公开（公告）日：——