1'-O-methylsucrose | 77895-08-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1'-O-methylsucrose
• 英文别名: Fruf1Me(b2-1a)Glc；(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-(methoxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 77895-08-0
• 化学式: C₁₃H₂₄O₁₁
• 分子量: 356.327
• InChiKey: CHVUPQUIPWLCRD-WSPRHHJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  179
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  蔗糖 、 alkaline earth salt of/the/ methylsulfuric acid 以 N,N-二甲基甲酰胺 为溶剂， 生成 1'-O-methylsucrose 、 2-O-methylsucrose 、 3'-O-methylsucrose
  参考文献：
  名称：

  Hamann, Carl Heinz; Fischer, Susanne; Polligkeit, Herbert, Zeitschrift fur Physikalische Chemie, 1994, vol. 185, # 1, p. 69 - 78

  摘要：

  DOI：

文献信息

• Identification of compounds that inhibit replication of human immunodeficiency virus
  申请人：Balzarini Maria Rene Jan

  公开号：US20050096319A1

  公开（公告）日：2005-05-05

  The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.

  本发明涉及一种新型化合物类别的发现，该化合物类别可以抑制人类免疫缺陷病毒（HIV）的复制，并提供了识别这些化合物的方法。具体而言，发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺可以抑制HIV在人血清中的复制。实施例包括识别抑制HIV的修饰甘氨酰胺化合物的方法，分离和合成修饰甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
• Studies of the alkaline degradation of mono-o-methylsucroses
  作者：Merilyn Manley-Harris、Geoffrey N. Richards

  DOI：10.1016/s0008-6215(00)85609-8

  日期：1981.3

  Abstract The alkaline degradation of a mixture of mono- O -methylsucroses has been studied. Some of the components of the mixture are degraded relatively rapidly at a similar to that of sucrose, but 1′- and 3′- O -methylsucrose are degraded much slowly. It is suggested that the alkaline degradation of sucrose occurs via two initial, and competing, rate-determining steps, each involving S N icB mechanisms

  摘要研究了单-O-甲基蔗糖混合物的碱降解。混合物的某些组分以与蔗糖相似的方式相对快速地降解，但是1'-和3'-O-甲基蔗糖的降解非常缓慢。建议蔗糖的碱性降解通过两个初始的竞争性速率确定步骤发生，每个步骤都涉及SN icB机制。这些反应涉及在C-1被1'-和3'-氧阴离子取代，分别产生1-和3-O-α-d-吡喃葡萄糖基-d-果糖。6'-氧阴离子的类似取代也可能在很小程度上发生。内部取代反应的产物对碱极其敏感，并且主要被降解为乳酸和d-葡萄糖基糖精酸。
• Process for producing isobutene from isobutylamine
  申请人：Metabolic Explorer

  公开号：EP2578559A1

  公开（公告）日：2013-04-10

  The present invention concerns a new process for the sustainable chemical synthesis of isobutene, using isobutylamine obtained by fermentation of a recombinant microorganism as starting material, based on a chemical conversion of an amine to an olefin (alkene).

  本发明涉及一种新的可持续化学合成异丁烯的过程，使用通过重组微生物发酵获得的异丁胺作为起始物质，并基于胺转化为烯烃（烯烃）的化学转化。
• Compounds That Inhibit Replication Of Human Immunodeficiency Virus
  申请人：Balzarini Maria Rene Jan

  公开号：US20080076824A1

  公开（公告）日：2008-03-27

  The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HUV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.

  本发明涉及一种新型化合物类别的发现，该类化合物能够抑制人类免疫缺陷病毒（HIV）的复制，并提供了鉴定这些化合物的方法。具体来说，发现经酶法制备的α-羟基甘氨酰胺和人工合成的α-羟基甘氨酰胺能够抑制HIV在人血清中的复制。实施例包括鉴定抑制HUV的改性甘氨酰胺化合物的方法，分离和合成改性甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
• COMPOSITION AND USE FOR PHOSPHODIESTERASE INHIBITORS
  申请人：Chervinsky Alex

  公开号：US20120157467A1

  公开（公告）日：2012-06-21

  Compositions and methods for enhancing the aesthetic appearance of the lip or lips of a human achieved by applying to the surface of the lip a composition containing a phosphodiesterase inhibitor, preferably a pyrazolopyrimidinone such as sildenafil or its citrate salt.

  本发明提供了一种用于增强人类唇部或唇部的美观外观的组合物和方法，其通过将含有磷酸二酯酶抑制剂的组合物（最好是吡唑啉并嘧啶酮，例如西地那非或其柠檬酸盐）涂抹于唇部表面来实现。