baicalein-6-O-glucoside | 529-43-1

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: baicalein-6-O-glucoside
• 英文别名: 6ξ-D-glucopyranosyloxy-5,7-dihydroxy-2-phenyl-chromen-4-one；6ξ-D-Glucopyranosyloxy-5,7-dihydroxy-2-phenyl-chromen-4-on；5,7-dihydroxy-2-phenyl-6-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
• CAS: 529-43-1；28279-72-3
• 化学式: C₂₁H₂₀O₁₀
• 分子量: 432.384
• InChiKey: WTYYPLMAODUDGW-ADLAMVQOSA-N

物化性质

• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 baicalein-6-O-glucoside 在 吡啶 作用下， 生成
  参考文献：
  名称：

  Dinda; Banika; Roychoudhury, Journal of the Indian Chemical Society, 2012, vol. 89, # 9, p. 1279 - 1281

  摘要：

  DOI：

文献信息

• Use of a Composition Comprising a Flavonol, A Flavonoid, and a Fatty Acid in the Treatment of Oxidative Injuries Due to Mitochondrial Dysfunction
  申请人：Robertson George

  公开号：US20170027902A1

  公开（公告）日：2017-02-02

  Compositions comprising a flavan-3-ol, a flavonoid, and a fatty acid have been demonstrated to mitigate the oxidative damage arising from mitochondrial dysfunction. In preferred embodiments, the composition comprises epicatechin, quercetin, and cicosapentaenoic acid (EPA) ethyl ester. The disorders to be treated include neurodegenerative disorders such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and multiple sclerosis (MS); neurological damage due to stroke; and ototoxicity arising from chemotherapy with cisplatin.
• [EN] USE OF A COMPOSITION COMPRISING A FLAVONOL, A FLAVONOID, AND A FATTY ACID IN THE TREATMENT OF OXIDATIVE INJURIES DUE TO MITOCHONDRIAL DYSFUNCTION<br/>[FR] UTILISATION D'UNE COMPOSITION CONTENANT UN FLAVONOL, UN FLAVONOÏDE ET UN ACIDE GRAS DANS LE TRAITEMENT DE LÉSIONS OXYDATIVES CAUSÉES PAR UN DYSFONCTIONNEMENT MITOCHONDRIAL
  申请人：ROBERTSON GEORGE

  公开号：WO2015154192A1

  公开（公告）日：2015-10-15

  Compositions comprising a flavan-3-ol, a flavonoid, and a fatty acid have been demonstrated to mitigate the oxidative damage arising from mitochondrial dysfunction. In preferred embodiments, the composition comprises epicatechin, quercetin, and eicosapentaenoic acid (EPA) ethyl ester. The disorders to be treated include neurodegenerative disorders such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and multiple sclerosis (MS); neurological damage due to stroke; and ototoxicity arising from chemotherapy with cisplatin.