6-(Benzyloxy)quinolin-2(1H)-one | 1080656-96-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(Benzyloxy)quinolin-2(1H)-one
• 英文别名: 6-(Benzyloxy)quinolin-2-ol；6-phenylmethoxy-1H-quinolin-2-one
• CAS: 1080656-96-7
• 化学式: C₁₆H₁₃NO₂
• 分子量: 251.285
• InChiKey: RFBUUFRSYHFQEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(Benzyloxy)quinolin-2(1H)-one 、 一氯丙酮 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以71%的产率得到6-benzyloxy-1-(2-oxopropyl)quinolin-2(1H)-one
  参考文献：
  名称：

  STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES

  摘要：

  Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N-1-and O-2-alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro-quinolin-2(1H)-ones under the same reaction conditions gave exclusively O-2-alkylated products.

  DOI：

  10.4067/s0717-97072015000100008

文献信息

• ORGANIC COMPOUNDS
  申请人：Dales Natalie

  公开号：US20090156615A1

  公开（公告）日：2009-06-18

  The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

  本发明提供了调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。还涵盖了利用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法以及包含这些衍生物的药物组合物。
• US8501746B2
  申请人：——

  公开号：US8501746B2

  公开（公告）日：2013-08-06
• US9701637B2
  申请人：——

  公开号：US9701637B2

  公开（公告）日：2017-07-11
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：NOVARTIS AG

  公开号：WO2007143597A9

  公开（公告）日：2010-11-11

  [EN] The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
  [FR] La présente invention concerne des dérivés hétérocycliques modulant l'activité de la stéaroyl-CoA désaturase. La présente invention englobe également des méthodes d'emploi de tels dérivés dans la modulation de l'activité de la stéaroyl-CoA désaturase ainsi que des compositions pharmaceutiques comprenant de tels dérivés.
• STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES
  作者：CHIA-LING CHEN、I-LI CHEN、JIH-JUNG CHEN、DAU-CHANG WEI、HAN-JIE HSIEH、KEN-MING CHANG、CHERNG-CHYI TZENG、TAI-CHI WANG

  DOI：10.4067/s0717-97072015000100008

  日期：——

  Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N-1-and O-2-alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro-quinolin-2(1H)-ones under the same reaction conditions gave exclusively O-2-alkylated products.