3,5-Dimethyl-4-acetyl-pyridin | 70390-44-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,5-Dimethyl-4-acetyl-pyridin
• 英文别名: 1-(3,5-dimethyl-pyridin-4-yl)-ethanone；4-acetyl-3,5-dimethylpyridine；1-(3,5-Dimethylpyridin-4-YL)ethanone
• CAS: 70390-44-2
• 化学式: C₉H₁₁NO
• 分子量: 149.192
• InChiKey: ZKJBKKNRSCBIPT-UHFFFAOYSA-N

物化性质

• 保留指数：
  1892;1893;1893;1894

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5-Dimethyl-4-acetyl-pyridin 在 溴 作用下， 以 氢溴酸 、 溶剂黄146 为溶剂， 生成 [4-amino-2-(4-sulfamoyl-phenylylamino)-thiazol-5-yl]-(3,5-dimethyl-pyridin-4-yl)-methanone
  参考文献：
  名称：

  Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors

  摘要：

  含有以下式（其中R1和R2如规范中定义）的CDK抑制二氨基噻唑化合物或其盐、前药或这些化合物或盐的活性代谢物的有效量的药物组合物，对于治疗癌症等疾病和疾病是有用的： 在优选实施例中，R1和R2独立地是未取代或取代的碳环或杂环芳基环结构。其中R2为邻位取代芳基的化合物特别是CDK4的有效抑制剂。

  公开号：

  US06569878B1

文献信息

• PROCESS FOR PRODUCING OPTICALLY ACTIVE SECONDARY ALCOHOL
  申请人：KANTO KAGAKU KABUSHIKI KAISHA

  公开号：US20150031920A1

  公开（公告）日：2015-01-29

  [Object] The object of this invention is to provide a method for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. [Solution] The method of producing an optically active secondary alcohol according to the present invention is characterized in that a substrate carbonyl compound (provided that 3-quinuclidinone, 3-quinuclidinone derivative having a substituent, and a ketone having an aromatic hydrocarbon group and a heterocycle are excluded) is reacted with hydrogen and/or a hydrogen donating compound in the presence of a ruthenium complex selected from the compounds expressed by following general formula (1) RuXYAB (1) [in the general formula (1), X and Y are the same or different from each other and denote a hydrogen atom or an anionic group, A denotes an optically active diphosphine expressed by the general formula (2), B denotes an amine compound expressed by following general formula (3)].

  本发明的目的是提供一种通过在高效率下使用一种作为催化剂的钌配合物，其中该钌配合物携带某种光学活性的二膦化合物和一种易于合成的胺化合物，从而在高光学纯度下加氢化底物羰基化合物生产光学活性二级醇的方法。 根据本发明的一种生产光学活性二级醇的方法的特征在于，在一种选择自下述通用式（1）RuXYAB所表示的化合物的钌配合物的存在下，将底物羰基化合物（假设排除3-喹啉酮、带有取代基的3-喹啉酮衍生物以及具有芳香烃基和杂环的酮）与氢气和/或氢供体化合物反应。[在通用式（1）中，X和Y相同或不同，表示氢原子或阴离子基团，A表示由通用式（2）表示的光学活性二膦，B表示由下述通用式（3）表示的胺化合物]。
• Compounds, pharmaceutical compositions, and methods for inhibiting cyclin-dependent kinases
  申请人：——

  公开号：US20030220326A1

  公开（公告）日：2003-11-27

  Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R 1 and R 2 are as defined in the specification) or their salts, or prodrugs or active metabolites of such compounds or salts, are useful for treating disorders and diseases such as cancer: 1 In preferred embodiments, R 1 and R 2 are independently unsubstituted or substituted carbocyclic or heterocyclic aryl ring structures. Compounds where R 2 is ortho-substituted aryl are especially potent inhibitors of CDKs such as CDK4.

  含有以下公式中CDK抑制二氨基噻唑化合物的有效量的药物组合物（其中R1和R2如规范所定义）或其盐，或这些化合物或盐的前药或活性代谢物，可用于治疗癌症等疾病和疾病。在首选实施例中，R1和R2分别是未取代或取代的碳环或杂环芳香环结构。其中R2为邻位取代芳香族的化合物特别是CDKs如CDK4的有效抑制剂。
• Process for producing optically active secondary alcohol
  申请人：Kanto Kagaku Kabushiki Kaisha

  公开号：EP2865446A1

  公开（公告）日：2015-04-29

  The object of this invention is to provide a method for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. The method of producing an optically active secondary alcohol according to the present invention is characterized in that a substrate carbonyl compound (provided that 3-quinuclidinone, 3-quinuclidinone derivative having a substituent, and a ketone having an aromatic hydrocarbon group and a heterocycle are excluded) is reacted with hydrogen and/or a hydrogen donating compound in the presence of a ruthenium complex selected from the compounds expressed by following general formula (1) RuXYAB (1) [in the general formula (1), X and Y are the same or different from each other and denote a hydrogen atom or an anionic group, A denotes an optically active diphosphine expressed by the general formula (2), B denotes an amine compound expressed by following general formula (3)].

  本发明的目的是提供一种高光学纯度的光学活性仲醇的制取方法，该方法是以某种光学活性二膦化合物和易于合成的胺化合物为配体的钌络合物为催化剂，通过高效率地氢化底物羰基化合物来制取光学活性仲醇。 根据本发明的生产光学活性仲醇的方法，其特征在于底物羰基化合物(但不包括3-奎宁环酮、具有取代基的3-奎宁环酮衍生物和具有芳香烃基和杂环的酮)在选自通式(1)RuXYAB(1)的化合物的钌络合物存在下与氢和/或氢捐赠化合物反应[在通式(1)中、X 和 Y 彼此相同或不同，表示氢原子或阴离子基团，A 表示通式 (2) 所表示的光学活性二膦，B 表示通式 (3) 所表示的胺化合物]。
• 4-Aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases
  申请人：AGOURON PHARMACEUTICALS, INC.

  公开号：EP1215208B1

  公开（公告）日：2006-07-12
• Catalyst and process for hydrogenating olefinically unsaturated compound
  申请人：JSR Corporation

  公开号：EP0974602B1

  公开（公告）日：2004-01-02