5-Ethoxy-6-[3-(tetrahydro-pyran-2-yloxy)-propoxy]-indan-1-one | 627518-65-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5-Ethoxy-6-[3-(tetrahydro-pyran-2-yloxy)-propoxy]-indan-1-one
• 英文别名: 5-ethoxy-6-[3-(oxan-2-yloxy)propoxy]-2,3-dihydroinden-1-one
• CAS: 627518-65-4
• 化学式: C₁₉H₂₆O₅
• 分子量: 334.412
• InChiKey: FQGMBTNBJABTCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-Ethoxy-6-[3-(tetrahydro-pyran-2-yloxy)-propoxy]-indan-1-one 、 1-乙氧基-3-异硫氰酸基-苯 在 lithium hexamethyldisilazane 、 溶剂黄146 、 甲基肼 作用下， 以 四氢呋喃 、 甲苯 、 乙醇 为溶剂， 反应 4.75h， 以83%的产率得到6-ethoxy-N-(3-ethoxyphenyl)-1-methyl-7-[3-(oxan-2-yloxy)propoxy]-4H-indeno[1,2-c]pyrazol-3-amine
  参考文献：
  名称：

  WO2008/94896

  摘要：

  公开号：
• 作为产物：
  描述：

  2-(3-氯丙氧基)四氢-2H-吡喃 、 5-ethoxy-6-hydroxy-1-indanone 在 potassium carbonate 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以87%的产率得到5-Ethoxy-6-[3-(tetrahydro-pyran-2-yloxy)-propoxy]-indan-1-one
  参考文献：
  名称：

  WO2008/94896

  摘要：

  公开号：

文献信息

• [EN] N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS<br/>[FR] 3-AMINOPYRAZOLES TRICYCLIQUES N-SUBSTITUES COMME INHIBITEURS DES RECEPTEURS DU PDFG
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2003097609A1

  公开（公告）日：2003-11-27

  The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the presentinvention and to methods for treating conditions such as tumors and other cell proliferative disorders.

  本发明涉及N-取代的三环3-氨基吡唑衍生物，其作为血小板源性生长因子受体（PDGF-R）激酶的抑制剂具有用途，以及制备该衍生物的方法。本发明还涉及包含本发明化合物的制药组合物，以及用于治疗肿瘤和其他细胞增殖性疾病的方法。
• N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
  申请人：——

  公开号：US20040082639A1

  公开（公告）日：2004-04-29

  The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.

  该发明涉及N-取代的三环3-氨基吡唑衍生物，它们可用作血小板源性生长因子受体（PDGF-R）激酶的抑制剂，以及制备该衍生物的方法。本发明还涉及包含本发明化合物的药物组合物，以及治疗肿瘤和其他细胞增殖性疾病的方法。
• N-substituted tricyclic 1-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
  申请人：Ho Yung Chih

  公开号：US20070142305A1

  公开（公告）日：2007-06-21

  The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell. proliferative disorders.

  本发明涉及N-取代的三环3-氨基吡唑衍生物，其可用作血小板源性生长因子受体（PDGF-R）激酶的抑制剂，以及制备该衍生物的方法。本发明进一步涉及包含本发明化合物的制药组合物，并用于治疗肿瘤和其他细胞增殖性疾病的方法。
• N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1506175B1

  公开（公告）日：2009-04-01
• N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS ANTI-MITOTIC TUBULIN POLYMERIZATION INHIBITORS
  申请人：Galemmo Robert A.

  公开号：US20080227821A1

  公开（公告）日：2008-09-18

  The invention is directed to compounds having the following structures: N-(3-ethoxyphenyl)-1,4-dihydro-6-ethoxy-7-(3-hydroxypropoxy)-1-methylindeno[1,2-c]pyrazole-3-amine; 3-[3-(3-Bromo-phenylamino)-6-ethoxy-1-methyl-1,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol; or 3-[3-(2-Chloro-pyridin-4-ylamino)-6-ethoxy-1-methyl-1,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol, and N-oxides, pharmaceutically acceptable salts, solvates, tautomers and stereochemical isomers thereof and the uses of such compounds as inhibitors of tubulin polymerization and for the treatment of solid tumors. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.