1,1,1-trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate | 853064-87-6

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1,1-trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate
• 英文别名: 5,5,5-Trifluoro-4-hydroxy-2-methyl-4-(trifluoromethyl)pentyl methacrylate；[5,5,5-trifluoro-4-hydroxy-2-methyl-4-(trifluoromethyl)pentyl] 2-methylprop-2-enoate
• CAS: 853064-87-6
• 化学式: C₁₁H₁₄F₆O₃
• 分子量: 308.221
• InChiKey: WNAVFWSIXYHORQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  1,1,1-trifluoro-2,5-dihydroxy-2-(trifluoromethyl)pentane 、 甲基锂 、 正丁基锂 、 甲基丙烯酰氯 在 1,1,1-trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate 作用下， 以to yield 35 g (76%) of the title compound as a clear colorless oil的产率得到1,1,1-trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate
  参考文献：
  名称：

  Precursors to fluoroalkanol-containing olefin monomers, and associated methods of synthesis and use

  摘要：

  本发明提供了烯烃氟代醇和氟代聚醇前体，用于制备氟代醇取代的α，β-不饱和酯。这些氟代醇取代的α，β-不饱和酯是烯烃，可轻松聚合以提供在光刻胶组合物中有用的氟代醇取代聚合物。还提供了合成烯烃氟代醇和氟代聚醇前体的方法。

  公开号：

  US07767866B2
• 作为试剂：
  描述：

  1,1,1-trifluoro-2,5-dihydroxy-2-(trifluoromethyl)pentane 、 甲基锂 、 正丁基锂 、 甲基丙烯酰氯 在 1,1,1-trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate 作用下， 以to yield 35 g (76%) of the title compound as a clear colorless oil的产率得到1,1,1-trifluoro-2-trifluoromethyl-2-hydroxy-4-methyl-5-pentyl methacrylate
  参考文献：
  名称：

  Precursors to Fluoroalkanol-Containing Olefin Monomers, and Associated Methods of Synthesis and Use

  摘要：

  本发明提供了烯烃氟代醇和氟代多元醇前体，用于制备氟代醇取代的α，β-不饱和酯。氟代醇取代的α，β-不饱和酯是烯烃，可轻松聚合以提供在光刻光阻组合物中有用的氟代醇取代聚合物。本发明还提供了合成烯烃氟代醇和氟代多元醇前体的方法。

  公开号：

  US20090177017A1

文献信息

• Precursors to fluoroalkanol-containing olefin monomers and associated methods of synthesis and use
  申请人：Breyta Gregory

  公开号：US20050124827A1

  公开（公告）日：2005-06-09

  The invention provides alkene fluoroalkanol and fluorinated polyol precursors to fluoroalkanol-substituted α,β-unsaturated esters. The fluoroalkanol-substituted α,β-unsaturated esters are olefins that can be readily polymerized to provide fluoroalkanol-substituted polymers useful in lithographic photoresist compositions. Also provided are methods for synthesizing the alkene fluoroalkanol and fluorinated polyol precursors.

  这项发明提供了烯烃氟烷醇和氟代多元醇前体，用于制备氟烷醇取代的α，β-不饱和酯。这些氟烷醇取代的α，β-不饱和酯是烯烃，可以方便地聚合，从而提供在光刻光阻组合物中有用的氟烷醇取代聚合物。还提供了合成烯烃氟烷醇和氟代多元醇前体的方法。
• [EN] BRANCHED PEG MOLECULES AND RELATED COMPOSITIONS AND METHODS<br/>[FR] MOLÉCULES DE PEG RAMIFIÉ, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：PHASERX INC

  公开号：WO2018126084A1

  公开（公告）日：2018-07-05

  Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

  揭示了分支聚乙二醇（PEG）分子，包括分支PEG-脂质和分支PEG-蛋白质，以及制备分支PEG分子的相关组合物和方法。还公开了相关的组合物、系统和方法，用于体内传递治疗和诊断试剂。
• Low activation energy photoresists
  申请人：Allen David Robert

  公开号：US20050124774A1

  公开（公告）日：2005-06-09

  Polymers containing an acetal or ketal linkage and their use in lithographic photoresist compositions, particularly in chemical amplification photoresists, are provided. The polymer is prepared from at least one first olefinic monomer containing an acetal or ketal linkage, the acid-catalyzed cleavage of which renders the polymer soluble in aqueous base; and at least one second olefinic monomer selected from (i) an olefinic monomer containing a pendant fluorinated hydroxyalkyl group R H , (ii) an olefinic monomer containing a pendant fluorinated alkylsulfonamide group R S , and (iii) combinations thereof. The acetal or ketal linkage may be contained within an acid-cleavable substituent R CL in the first olefinic monomer. A method for using the photoresist compositions containing these polymers in preparing a patterned substrate is also provided in which the polymer is rendered soluble in aqueous base at a temperature of less than about 100° C. by acid-catalyzed deprotection of pendent acetal- or ketal-protected carboxylic acid groups.

  提供包含缩醛或缩酮键的聚合物及其在印刷光阻组合物中的使用，特别是在化学放大光阻中的使用。该聚合物由至少一个含有缩醛或缩酮键的第一烯丙基单体制备而成，酸催化裂解使聚合物在水性碱中溶解；以及至少一个第二烯丙基单体，选自（i）含有侧链氟代羟基烷基RH的烯丙基单体，（ii）含有侧链氟代烷基磺酰胺基团RS的烯丙基单体，以及（iii）其组合物。第一烯丙基单体中的缩醛或缩酮键可以包含在酸可裂解的取代基RCL中。还提供了一种使用这些聚合物的光阻组合物在制备图案化基板中的方法，其中通过酸催化去保护侧链缩醛或缩酮保护羧酸基团，使聚合物在低于约100°C的温度下在水性碱中溶解。
• Percursors to fluoroalkanol-containing olefin monomers, and associated methods of synthesis and use
  申请人：International Business Machines Corporation

  公开号：US07521582B2

  公开（公告）日：2009-04-21

  The invention provides alkene fluoroalkanol and fluorinated polyol precursors to fluoroalkanol-substituted α,β-unsaturated esters. The fluoroalkanol-substituted α,β-unsaturated esters are olefins that can be readily polymerized to provide fluoroalkanol-substituted polymers useful in lithographic photoresist compositions. Also provided are methods for synthesizing the alkene fluoroalkanol and fluorinated polyol precursors.

  该发明提供了烯烃氟代醇和氟代多元醇前体，用于制备氟代醇取代的α，β-不饱和酯。氟代醇取代的α，β-不饱和酯是可轻易聚合以提供在光刻光阻组成中有用的氟代醇取代聚合物的烯烃。此外，还提供了用于合成烯烃氟代醇和氟代多元醇前体的方法。
• Polymeric Nanoparticles for Ultrasound Imaging and Therapy
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20140243664A1

  公开（公告）日：2014-08-28

  Provided herein are nanobubbles designed for use in ultrasound-mediated ablation of cancer cells. The nanobubbles undergo ultrasound-mediated cavitation at an ablation threshold which is significantly decreased, relative to standard ultrasound-mediated treatment of cancer cells. In exemplary embodiments, the nanobubbles comprise an amphiphilic ABC triblock copolymer, wherein block A comprises a hydrophilic polymer, block B comprises a crosslinking polymer, and block C comprises a hydrophobic copolymer comprising (i) methyl methacrylate (MMA) and (ii) a fluorinated monomer, wherein the fluorinated monomer is present in the hydrophobic copolymer of block C at 25 mole percent or less. Related treatment and diagnostic methods, as well as materials relating to the nanobubbles are provided herein. Methods of making a random copolymer are furthermore provided herein.

  本文提供了一种设计用于超声波介导的癌细胞消融的纳米气泡。相较于标准的超声波介导癌细胞治疗，这些纳米气泡在消融阈值上经历了超声波介导空化的显著降低。在示例实施方案中，纳米气泡包括一种两性ABC三嵌段共聚物，其中块A包括一种亲水性聚合物，块B包括一种交联聚合物，而块C则包括一种疏水性共聚物，该疏水性共聚物包括(i)甲基丙烯酸甲酯(MMA)和(ii)一种氟化单体，其中该氟化单体在块C的疏水性共聚物中的摩尔分数为25%或更少。本文还提供了相关的治疗和诊断方法，以及与纳米气泡相关的材料。此外，本文还提供了一种制备随机共聚物的方法。