3,5,7,9-undecatetraen-2-one | 75143-19-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,5,7,9-undecatetraen-2-one
• 英文别名: undeca-3t,5t,7t,9t-tetraen-2-one；undeca-3,5,7,9-tetraen-2-one；Undeca-3t,5t,7t,9t-tetraen-2-on；Undeca-3,5,7,9-tetraen-2-on；(3E,5E,7E,9E)-undeca-3,5,7,9-tetraen-2-one
• CAS: 75143-19-0
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: YWFNISRBRXGLDR-BYFNFPHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,5,7,9-undecatetraen-2-one 、 β-dimethylaminoacrolein acetal aminal 以25%的产率得到(1E,3E,6E,8E,10E,12E)-1-Dimethylamino-tetradeca-1,3,6,8,10,12-hexaen-5-one
  参考文献：
  名称：

  Synthesis of polyenic bis-?,??- and mono-?-dimethylamino ketones

  摘要：

  DOI：

  10.1007/bf00958821
• 作为产物：
  描述：

  2,4,6-辛三烯醛 、 丙酮 在 sodium ethanolate 作用下， 生成 3,5,7,9-undecatetraen-2-one
  参考文献：
  名称：

  Fischer; Schulze, Chemische Berichte, 1942, vol. 75, p. 1469

  摘要：

  DOI：

文献信息

• PARA-QUINOL DERIVATIVES AND METHODS OF STEREO SELECTIVELY SYNTHESIZING AND USING SAME
  申请人：Plourde Guy L.

  公开号：US20090318548A1

  公开（公告）日：2009-12-24

  This application relates to para-quinol derivatives, such as analogues of manumycins, aranorosins and gymnastatins. This application also relates to methods of synthesizing and using the para-quinol derivatives. In one embodiment of the invention a compound having the chemical structure (I) is provided wherein X 1 and X 2 are carbon atoms either joined by double bond or joined by a single bond and comprising constituents of an epoxide ring or a hydroxyethylene moiety; X 3 and X 4 are carbon atoms either joined by double bond or joined by a single bond and comprising constituents of an epoxide ring; R 1 is selected from the group consisting of branched alkyl chains, unbranched alkyl chains, cycloalkyl groups, aromatic groups, alcohols, ethers, amines, and substituted or unsubstituted ureas, esters, aldehydes and carboxylic acids; and R 2 is selected from the group consisting of H, OH and NHR 3 wherein R 3 is a nitrogen protecting group. In a particular embodiment of the invention R 1 is a polyunsaturated carbon chain as found in biologically active manumycins. The applicant's synthetic method may involve diasteroselective formation of a spirolactone in an oxidative spiroannulation process using tyrosine or a tyrosine derivative having a chiral centre as a starting material.

  本申请涉及对位喹啉衍生物，例如曼纽霉素、阿拉诺罗辛和体操霉素的类似物。本申请还涉及合成和使用对位喹啉衍生物的方法。在发明的一个实施例中，提供了具有化学结构（I）的化合物，其中X1和X2是由双键连接或单键连接的碳原子，并包括环氧环或羟基乙烯基的组分；X3和X4是由双键连接或单键连接的碳原子，并包括环氧环的组分；R1选自支链烷基链，直链烷基链，环烷基团，芳香族团，醇，醚，胺和取代或未取代的脲、酯、醛和羧酸；R2选自H，OH和NHR3，其中R3是氮保护基。在发明的一个特定实施例中，R1是生物活性曼纽霉素中发现的多不饱和碳链。申请人的合成方法可能涉及使用酪氨酸或手性中心的酪氨酸衍生物作为起始材料，在氧化螺环化过程中二面体选择性地形成螺内酯。
• Nasarow et al., Doklady Akademii Nauk SSSR, 1958, vol. 122, p. 82,85
  作者：Nasarow et al.

  DOI：——

  日期：——
• KRASNAYA ZH. A.; STYTSENKO T. S.; PROKOFEV E. P.; KUCHEROV V. F., IZV. AN CCCP. CEP. XIM., 1980, HO 6, 1362-1373
  作者：KRASNAYA ZH. A.、 STYTSENKO T. S.、 PROKOFEV E. P.、 KUCHEROV V. F.

  DOI：——

  日期：——
• Polyene polyketides, processes for their production and their use as a pharmaceutical
  申请人：Zazopoulos Emmanuel

  公开号：US20070275436A1

  公开（公告）日：2007-11-29

  This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis ; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.
• US7416868B2
  申请人：——

  公开号：US7416868B2

  公开（公告）日：2008-08-26