1-N-acetyl-2-amino-2-deoxy-β-D-glucopyranosylamine | 18615-50-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-N-acetyl-2-amino-2-deoxy-β-D-glucopyranosylamine
• 英文别名: N-((2R,3R,4R,5S,6R)-3-Amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)acetamide；N-[(2R,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]acetamide
• CAS: 18615-50-4
• 化学式: C₈H₁₆N₂O₅
• 分子量: 220.225
• InChiKey: LWYDKUAWJKUSJT-FMDGEEDCSA-N

物化性质

• 熔点：
  103-112°C
• 沸点：
  556.2±50.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  125
• 氢给体数：
  5
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 海关编码：
  2932999099

反应信息

• 作为产物：
  描述：

  1-N-乙酰基-2-乙酰氨基-beta-吡喃葡萄糖基胺 在 肼 作用下， 反应 30.0h， 以35%的产率得到1-N-acetyl-2-amino-2-deoxy-β-D-glucopyranosylamine
  参考文献：
  名称：

  Degradation during the hydrazinolysis of 2-acetamido-1-N-acyl-2-deoxy-β-d-glucopyranosylamines

  摘要：

  DOI：

  10.1016/0008-6215(83)88252-4

文献信息

• Further studies of the hydrazinolysis of 2-acetamido-1-N-acyl-2-deoxy-β-d-glucopyranosylamines
  作者：Ping W. Tang、J.Michael Williams

  DOI：10.1016/0008-6215(83)84008-7

  日期：1983.9

  Abstract 1-Deoxy- d -fructose hydrazone is shown to be the major product of the hydrazinolysis of 2-amino-2-deoxy- d -glucose hydrazone and can be detected as a minor product of the hydrazinolysis of 2-acetamido-1- N -acetyl-2-deoxy-β- d -glucopyranosylamine. The hydrazinolysis conditions (100°, 30 h, no catalyst) of Bayard and Montreuil are inefficient for the cleavage of the amide groups of 2-acetamido-

  摘要1-脱氧-d-果糖被证明是2-氨基-2-脱氧-d-葡萄糖的肼解的主要产物，可被检测为2-乙酰氨基-1-的肼解的次要产物。 N-乙酰基-2-脱氧-β-d-吡喃葡萄糖基胺。Bayard和Montreuil的肼解条件（100°，30 h，无催化剂）对2-乙酰氨基-1- N-乙酰基-2-脱氧-β-d-吡喃葡萄糖胺的酰胺基的裂解无效，原料和1-N-乙酰基-2-氨基-2-脱氧-β-d-吡喃葡萄糖基胺占产物混合物的70％。在相同条件下，2-乙酰氨基-1-N-（1-β-天冬氨酰）-2-脱氧-β-d-葡萄糖吡喃糖胺的肼解反应一起得到2-氨基-2-脱氧-d-葡萄糖。含约14％的1-脱氧-d-果糖。调用天冬酰胺残基的羧基参与以说明天冬酰胺衍生物的更大反应性。当应用于天冬酰胺衍生物时，硫酸肼催化的肼解作用产生较高的产率（44％）的1-脱氧-d-果糖ose。讨论了这些结果与糖肽和糖蛋白的肼解作用有关。
• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Polymeric Coatings Incorporating Bioactive Enzymes for Catalytic Function
  申请人：McDaniel C. Steven

  公开号：US20120097194A1

  公开（公告）日：2012-04-26

  Disclosed herein are materials including a polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a coating, a textile finish or a wax; a filler for such a polymeric material or a surface treatment, which includes an enzyme such as an esterase (e.g., a lipolytic enzyme, an organophosphorus compound degradation enzyme), wherein the enzyme decontaminates a chemical from the surface of the material. Also disclosed herein are methods of cleaning a surface of a material that comprises an enzyme.

  本文公开了一种材料，包括聚合物材料，例如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；表面处理，例如涂层、纺织品处理或蜡；用于上述聚合物材料或表面处理的填料，其中包括酶，例如酯酶（例如脂肪水解酶、有机磷化合物降解酶），其中酶可从材料表面去除化学物质。本文还公开了一种清洁含有酶的材料表面的方法。
• Polymeric Coatings Incorporating Bioactive Enzymes for Cleaning a Surface
  申请人：Wales Melinda

  公开号：US20110240064A1

  公开（公告）日：2011-10-06

  Disclosed herein are a materials such as a coating, such as an architectural coating or a CARC coating, comprising a lipolytic enzyme or organophosphorous compound degrading enzyme. Also disclosed herein are methods of decontaminating a surface comprising such a material from a chemical substrate of an enzyme such as a lipid or an organophosphorus compound.

  本文公开了一种材料，例如涂层，如建筑涂层或CARC涂层，包括脂肪水解酶或有机磷化合物降解酶。本文还公开了一种从酶的化学底物，例如脂质或有机磷化合物，中去除此类材料表面的污染物的方法。
• Visual Assays for Coatings Incorporating Bioactive Enzymes for Catalytic Functions
  申请人：Williams Eric B.

  公开号：US20110250626A1

  公开（公告）日：2011-10-13

  Disclosed herein are materials such as a coating, comprising a lipolytic enzyme or organophosphrous compound degrading enzyme. Also disclosed herein are methods of visually detecting enzyme activity in a coating by contacting the coating with a substrate of an enzyme and a visual indicator that changes appearance upon production of a product of enzyme activity on a tack-free coating surface.

  本文公开了一种涂层材料，包括脂肪水解酶或有机磷化合物降解酶。本文还公开了一种方法，通过将涂层与酶底物和视觉指示剂接触，以在无粘涂层表面产生酶活性产物时改变外观来检测酶活性的方法。