1-(4-ethoxyphenyl)-2-methyl-1-propanone | 72846-63-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-ethoxyphenyl)-2-methyl-1-propanone
• 英文别名: 1-(4-ethoxy-phenyl)-2-methyl-propan-1-one；1-(4-Aethoxy-phenyl)-2-methyl-propan-1-on；1-(4-Ethoxyphenyl)-2-methylpropan-1-one
• CAS: 72846-63-0
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: POGPSKUWSGOZRN-UHFFFAOYSA-N

物化性质

• 沸点：
  297.8±13.0 °C(Predicted)
• 密度：
  0.986±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-ethoxyphenyl)-2-methyl-1-propanone 在 乙醇 、 sodium 作用下， 生成 1-ethoxy-4-(2-methyl-propenyl)-benzene
  参考文献：
  名称：

  Antifungal Pharmacodynamic Characteristics of Amphotericin B againstTrichosporon asahii, Using Time-Kill Methodology

  摘要：

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.

  DOI：

  10.1111/j.1348-0421.2002.tb02663.x
• 作为产物：
  描述：

  异丁酰氯 、 苯乙醚 以85.4%的产率得到1-(4-ethoxyphenyl)-2-methyl-1-propanone
  参考文献：
  名称：

  2-（4-乙氧基苯基）-2-甲基丙醇的合成方法

  摘要：

  本发明公开了一种2‑（4‑乙氧基苯基）‑2‑甲基丙醇的合成方法，属于有机合成技术领域。该方法以廉价苯乙醚为原料，以离子液体为反应溶剂进行异丁酰氯傅克酰基化，反应完后甲基叔丁基醚萃取分液，醚相水洗干燥，回收醚相后蒸馏提纯得产物，加入叔丁基醚，加入计量的液溴溴化，溴化完成后水洗后处理结晶，加入石油醚，在对甲苯磺酸的催化作用下与新戊二醇回流脱水缩合即得缩合物。缩合物在溶剂中与催化剂锌盐高温转位，然后直接碱溶液水解，最后在硼氢化钠和三氯化铝的作用下还原得到2‑（4‑乙氧基苯基）‑2‑甲基丙醇。该方法收率高，安全环保，操作简单，离子液体补加少许三氯化铝后重新套用，水解反应重新生成新戊二醇也可回收套用。

  公开号：

  CN112723999A

文献信息

• Palladium-Catalyzed Reaction of [60]Fullerene with Aroyl Compounds via Enolate-Mediated sp² C–H Bond Activation and Hydroxylation
  作者：Yi-Teng Yan、Wei Gao、Bo Jin、Dong-Shi Shan、Ru-Fang Peng、Shi-Jin Chu

  DOI：10.1021/acs.joc.7b02620

  日期：2018.1.19

  palladium-catalyzed reaction of [60]fullerene (C60) with aroyl compounds via enolate-mediated C–H activation and hydroxylation has been exploited for the first time to synthesize novel C60-fused dihydrofurans, and rare 1,4-fullerenols. Further functionalization including etherification, and esterification of synthesized 1,4-fullerenols provided efficient access to versatile fullerene derivatives. Moreover, a plausible

  通过烯醇酸介导的CH活化和羟基化，[60]富勒烯（C 60）与芳酰基化合物的便捷，高效的钯催化反应首次被用于合成新型的C 60稠合的二氢呋喃，这种稀有反应1 ，4-富勒烯醇。进一步的功能化包括合成的1，4-富勒烯醇的醚化和酯化，可以有效地获得通用的富勒烯衍生物。此外，提出了导致所观察到的产物的合理的反应机理。
• Importance of β Phenyl Group in Ipso Substitution of Arylvinyl Cations
  作者：Tsugio Kitamura、Shin-ichi Soda、Ichizo Nakamura、Tetsuro Fukuda、Hiroshi Taniguchi

  DOI：10.1246/cl.1991.2195

  日期：1991.12

  Intramolecular and intermolecular ipso substitutions of arylvinyl cations, i.e., α-[p-(2-hydroxyethoxy)phenyl]vinyl cations and α-(p-methoxyphenyl)vinyl cations, were studied with respect to the effect of the β substituent and phenyl group as the β substituent was found to exert a significant influence on the ipso substitution.

  研究了芳基乙烯基阳离子（即 α-[对-(2-羟乙氧基)苯基]乙烯基阳离子和 α-(对-甲氧基苯基)乙烯基阳离子）的分子内和分子间异位取代，发现 β 取代基和苯基对异位取代有显著影响。
• ISOSORBIDE DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS, TASTANTS, AND TASTE ENHANCERS
  申请人：TACHDJIAN Catherine

  公开号：US20130295261A1

  公开（公告）日：2013-11-07

  The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,

  本发明提供以下式子及其特定亚属或种类的异山梨酯衍生物，作为味道或口感调节剂，特别是让食品、饮料和其他食品组合物具有鲜美（鲜味）口感的调节剂、风味剂和风味增强剂。
• Benzimidazole derivatives
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US10752611B2

  公开（公告）日：2020-08-25

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）化合物或其药学上可接受的盐、酯或原药： 它们能抑制含 RNA 的病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物可干扰丙型肝炎病毒的生命周期，也可用作抗病毒药物。本发明进一步涉及包含上述化合物的药物组合物，用于给丙型肝炎病毒感染者用药。本发明还涉及通过施用包含本发明化合物的药物组合物治疗受试者感染 HCV 的方法。
• Gattermann; Ehrhardt; Maisch, Chemische Berichte, 1890, vol. 23, p. 1202
  作者：Gattermann、Ehrhardt、Maisch

  DOI：——

  日期：——