1-ethoxy-4-(2-methyl-propenyl)-benzene | 51422-04-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-ethoxy-4-(2-methyl-propenyl)-benzene
• 英文别名: 4-(2-methyl-propenyl)-phenetole；4-(2-Methyl-propenyl)-phenetol；1-(p-Ethoxyphenyl)-2-methylpropene；1-ethoxy-4-(2-methylprop-1-enyl)benzene
• CAS: 51422-04-9
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: DGGDNZWUJLOLCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-ethoxy-4-(2-methyl-propenyl)-benzene 在 亚硝酰氯 作用下， 以 乙醚 为溶剂， 生成 5-(4-ethoxy-phenyl)-4,4-dimethyl-4,5-dihydro-[1,2,3]oxadiazole 3-oxide
  参考文献：
  名称：

  Ogloblin,K.A. et al., Russian Journal of Organic Chemistry, 1973, vol. 9, p. 2252 - 2257

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(4-ethoxyphenyl)-2-methyl-1-propanone 在 乙醇 、 sodium 作用下， 生成 1-ethoxy-4-(2-methyl-propenyl)-benzene
  参考文献：
  名称：

  Antifungal Pharmacodynamic Characteristics of Amphotericin B againstTrichosporon asahii, Using Time-Kill Methodology

  摘要：

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.

  DOI：

  10.1111/j.1348-0421.2002.tb02663.x

文献信息

• An Electrochemical Cinnamyl C—H Amination Reaction Using Carbonyl Sulfamate
  作者：Shuai Liu、Jin Li、Dalin Wang、Feng Liu、Xu Liu、Yongyuan Gao、Dai Jie、Xu Cheng

  DOI：10.1002/cjoc.201900028

  日期：2019.6

  An electrochemical cinnamyl C—H amination reaction in the absence of transition metal catalyst and oxidant was reported. The choice of carbonyl sulfamate as nitrogen source is the key to achieve desired chemoselectivity. A series of terminal amine derivatives are prepared using this protocol and the sulfonyl group can be removed with basic hydrolysis. The reaction is suggested to proceed via a continuous

  报道了在不存在过渡金属催化剂和氧化剂的情况下的电化学肉桂基CH胺化反应。选择氨基磺酸羰基酯作为氮源是实现所需化学选择性的关键。使用该方案制备了一系列末端胺衍生物，并且可以通过碱性水解除去磺酰基。建议该反应通过连续的阳极氧化，去质子化，阳极氧化和分子间亲核加成途径进行，这证明了电化学肉桂酸CH胺化的第一个例子。
• Rhodium(II)-Catalyzed Allylic 1,3-Diamination
  作者：Beiqi Yang、Xinyu Liu、Aiwen Yu、Qi Yang、Yuanhua Wang

  DOI：10.1021/acscatal.2c04086

  日期：2022.11.4

  ulfonamides) catalyzed by rhodium(II) is reported herein. The isomers of the terminal and internal alkenes, even mixtures, all provided the same allylic 1,3-diamine products under mild reaction conditions. The resulting diaminated products can be derived to functionalized diamines and can further generate allylic triamines. Mechanistic studies revealed that the rhodium(II) compounds catalyzed a variety

  易得烯烃与N的分子间 1,3-二胺化反应本文报道了由铑(II)催化的-氟双(苯磺酰胺)。末端和内部烯烃的异构体，甚至混合物，都在温和的反应条件下提供相同的烯丙基 1,3-二胺产物。所得二胺化产物可衍生为官能化二胺，并可进一步生成烯丙基三胺。机理研究表明，铑（II）化合物在反应过程中基于其单电子氧化还原催化循环催化了多种化学转化，特别是末端烯烃中的自由基极性交叉和烯丙基C-H键的直接活化，然后是自由基交叉。 -偶联内部烯烃。这些结果显示了铑 (II) 在 C-H 胺化反应中的潜力以及众所周知的铑类氮氧化物的转化。
• Anti-Bacterial Compounds
  申请人：Parker Jane Katy

  公开号：US20080096894A1

  公开（公告）日：2008-04-24

  Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).