9,9'-(1,4-phenylene)bis(10-(4-chlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-dione) | 1221445-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9,9'-(1,4-phenylene)bis(10-(4-chlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-dione)
• 英文别名: 9,9'-(1,4-Phenylene)bis(10-(4-chlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydroacridine-1,8(2h,5h,9h,10h)-dione)；10-(4-chlorophenyl)-9-[4-[10-(4-chlorophenyl)-3,3,6,6-tetramethyl-1,8-dioxo-4,5,7,9-tetrahydro-2H-acridin-9-yl]phenyl]-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-acridine-1,8-dione
• CAS: 1221445-66-4
• 化学式: C₅₂H₅₄Cl₂N₂O₄
• 分子量: 841.918
• InChiKey: MKLHZUUYQFAOEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  60
• 可旋转键数：
  4
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对苯二甲醛 、 对氯苯胺 、 5,5-二甲基-1,3-环己二酮 在 1-methylimidazolium tricyanomethanide 作用下， 以 neat (no solvent) 为溶剂， 反应 0.5h， 以93%的产率得到9,9'-(1,4-phenylene)bis(10-(4-chlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-dione)
  参考文献：
  名称：

  一种使用1-甲基咪唑三氰胺{[HMIM] C（CN）3 }作为纳米结构熔融盐催化剂合成1,8-二氧杂硼氢化hydro啶衍生物的简便方法

  摘要：

  达到为1,8- dioxodecahydroacridine衍生物的合成的实用和方便的方法通过在1-甲基咪唑三氰基{[HMIM存在环状1,3-二酮，醛和各种苯胺或乙酸铵的一锅缩合反应] C（CN）3 }在室温下为纳米结构熔盐（NMS）催化剂。在目前的工作中，将首次报告三十多种产品。

  DOI：

  10.1016/j.molliq.2016.03.006

文献信息

• Synthesis and antimicrobial activities of novel bisacridine-1,8-dione derivatives
  作者：Muharrem Kaya、Yılmaz Yıldırır、Gökçen Y. Çelik

  DOI：10.1007/s00044-010-9321-6

  日期：2011.4

  A series of bisacridine-1,8-dione derivatives were synthesized by one-pot reaction of aromatic dialdehydes, dimedone or cyclohexane-1,3-dione and primer aromatic amines in acetonitrile to utilizing Amberlyst-15 as a heterogeneous catalyst. The structures of compounds were characterized by FT-IR, NMR, and elemental analysis. Antimicrobial activities of these compounds were determined by using the disc diffusion method against to these gram-positive and gram-negative bacteria and yeast. The results were compared with reference discs.
• A convenient method for the synthesis of 1,8-dioxodecahydroacridine derivatives using 1-methylimidazolium tricyanomethanide {[HMIM]C(CN)3} as a nanostructured molten salt catalyst
  作者：Mohammad Ali Zolfigol、Neda Bahrami-Nejad、Saeed Baghery

  DOI：10.1016/j.molliq.2016.03.006

  日期：2016.6

  A practical and convenient method for the synthesis of 1,8-dioxodecahydroacridine derivatives was achieved via the one-pot condensation reaction of cyclic 1,3-diketone, aldehydes and various anilines or ammonium acetate in the presence of 1-methylimidazolium tricyanomethanide [HMIM]C(CN)3} as a nanostructured molten salt (NMS) catalyst at room temperature. In the present work, more than thirty products

  达到为1,8- dioxodecahydroacridine衍生物的合成的实用和方便的方法通过在1-甲基咪唑三氰基[HMIM存在环状1,3-二酮，醛和各种苯胺或乙酸铵的一锅缩合反应] C（CN）3 }在室温下为纳米结构熔盐（NMS）催化剂。在目前的工作中，将首次报告三十多种产品。