2-[[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol | 4892-48-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 4892-48-2
• 化学式: C₁₅H₂₂O₉
• 分子量: 346.33
• InChiKey: RJWJHRPNHPHBRN-MBUGLWNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  149
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Composition for preventing or treating neurological disorder comprising aucubin
  申请人：University-Industry Cooperation Group of Kyung Hee University

  公开号：US11166970B2

  公开（公告）日：2021-11-09

  The present invention relates to a composition for preventing or treating a neurological disorder, comprising aucubin. Specifically, the present invention relates to a pharmaceutical composition for preventing or treating mental illness, comprising aucubin or a pharmaceutically acceptable salt thereof as an active ingredient, to a food composition, to a method for treating mental illness, and to a composition for maintaining the survival of GABAergic neurons, promoting the regeneration of GABAergic neurons, or preventing the apoptosis of GABAergic neurons. The aucubin according to the present invention exhibits effects of maintaining the survival of GABAergic neurons, promoting the regeneration of GABAergic neurons, preventing the apoptosis of GABAergic neurons, and promoting the production of GABA which is a neurotransmitter, and thus, the aucubin can be effectively used in the prevention or treatment of mental illnesses such as ADHD or autism, etc, which are caused by the deficiency of GABAergic neurons.

  本发明涉及一种用于预防或治疗神经系统疾病的组合物，其中包含杜鹃素。具体地说，本发明涉及一种预防或治疗精神疾病的药物组合物，其中包含作为活性成分的杜仲甙或其药学上可接受的盐；本发明还涉及一种食品组合物；本发明还涉及一种治疗精神疾病的方法；本发明还涉及一种维持 GABA 能神经元存活、促进 GABA 能神经元再生或防止 GABA 能神经元凋亡的组合物。 根据本发明的紫丁香素具有维持 GABA 能神经元存活、促进 GABA 能神经元再生、防止 GABA 能神经元凋亡、促进神经递质 GABA 生成的功效，因此，紫丁香素可有效用于预防或治疗因 GABA 能神经元缺乏而导致的多动症或自闭症等精神疾病。
• COMPOSITION FOR PREVENTING OR TREATING NEUROLOGICAL DISORDER COMPRISING AUCUBIN
  申请人：University-Industry Cooperation Group of Kyung Hee University

  公开号：US20200360410A1

  公开（公告）日：2020-11-19

  The present invention relates to a composition for preventing or treating a neurological disorder, comprising aucubin. Specifically, the present invention relates to a pharmaceutical composition for preventing or treating mental illness, comprising aucubin or a pharmaceutically acceptable salt thereof as an active ingredient, to a food composition, to a method for treating mental illness, and to a composition for maintaining the survival of GABAergic neurons, promoting the regeneration of GABAergic neurons, or preventing the apoptosis of GABAergic neurons. The aucubin according to the present invention exhibits effects of maintaining the survival of GABAergic neurons, promoting the regeneration of GABAergic neurons, preventing the apoptosis of GABAergic neurons, and promoting the production of GABA which is a neurotransmitter, and thus, the aucubin can be effectively used in the prevention or treatment of mental illnesses such as ADHD or autism, etc, which are caused by the deficiency of GABAergic neurons.