2-(1,4-dioxaspiro[4.5]decan-7-yl)-N-ethylacetamide | 845555-57-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1,4-dioxaspiro[4.5]decan-7-yl)-N-ethylacetamide
• CAS: 845555-57-9
• 化学式: C₁₂H₂₁NO₃
• 分子量: 227.304
• InChiKey: GGNIWHUCKYKKCK-UHFFFAOYSA-N

物化性质

• 沸点：
  406.5±20.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(1,4-dioxaspiro[4.5]decan-7-yl)-N-ethylacetamide 在 LiAlBH₄ 作用下， 以 四氢呋喃 为溶剂， 生成 2-(1,4-dioxaspiro[4.5]decan-7-yl)-N-ethylethanamine
  参考文献：
  名称：

  A practical entry to C18-constrained-E-ring analogues of methyllycaconitine (MLA): a concise new stereoselective approach to 8-oxa-decahydroisoquinolines accompanied by a simple microwaves-assisted synthesis of the succinimidobenzoate appendage of MLA

  摘要：

  A Mannich-type intramolecular cyclization afforded access to a 8-oxa-decahydroisoquinoline heterocyclic system. Good stereoselectivity was observed. A promising microwave-assisted synthesis of the methylsuccinimidobenzoate moiety of methyllycaconitine has also been carried out. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.12.029
• 作为产物：
  描述：

  (3-氧代环己基)-乙酸乙酯 在 氢气 作用下， 以 水 为溶剂， 生成 2-(1,4-dioxaspiro[4.5]decan-7-yl)-N-ethylacetamide
  参考文献：
  名称：

  A practical entry to C18-constrained-E-ring analogues of methyllycaconitine (MLA): a concise new stereoselective approach to 8-oxa-decahydroisoquinolines accompanied by a simple microwaves-assisted synthesis of the succinimidobenzoate appendage of MLA

  摘要：

  A Mannich-type intramolecular cyclization afforded access to a 8-oxa-decahydroisoquinoline heterocyclic system. Good stereoselectivity was observed. A promising microwave-assisted synthesis of the methylsuccinimidobenzoate moiety of methyllycaconitine has also been carried out. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.12.029