[18F]N-(4-phenylbutyl)-4-(4-fluorobenzoyl)piperidine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [18F]N-(4-phenylbutyl)-4-(4-fluorobenzoyl)piperidine
• 英文别名: (4-(18F)fluoranylphenyl)-[1-(4-phenylbutyl)piperidin-4-yl]methanone
• 化学式: C₂₂H₂₆FNO
• 分子量: 338.455
• InChiKey: FTJXZACAQRDRNT-VNRZBHCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(4-phenylbutyl)-4-(4-nitrobenzoyl)piperidine 在 potassium carbonate 、 4,7,13,16,21,24-六氧-1,10-二氮双环[8.8.8]二十六烷 、 氢氟酸 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 生成 [18F]N-(4-phenylbutyl)-4-(4-fluorobenzoyl)piperidine
  参考文献：
  名称：

  Radiosynthesis of [18F]N-(4-phenylbutyl)-4-(4-fluorobenzoyl)piperidine for studying serotonin 5-HT2a receptors

  摘要：

  N-(4-Phenylbutyl)-4-(4-fluorobenzoyl)pipe [4-PBFBP] shows highly selective binding to serotonin 5-HT2A receptors with high affinity. In this study, we prepared [F-18]4-PBFBP for in vivo study of 5-HT2A receptors in the brain using positron emission tomography (PET). Nucleophilic aromatic displacement of N-(4-phenylbutyl)-4-(4-nitrobenzoyl)piperidine by no carrier added [F-18]fluoride which was solubilized by Kryptofix 222 in DMSO produced [F-18]4-PBFBP with high specific radioactivity. The product was purified by reversed phase preparative HPLC and was extracted from the collected eluate by SEP-PAK(R) C18 cartridge prior to formulation. The radiochemical yield of the final product was 15 +/- 1.8 % (mean +/- S.D. of three experiments) with decay correction and the specific activity was 113 +/- 27 GBq/mu mol (mean +/- S.D. of three experiments) at E.O.S. after a total preparation time of about 160 min. The radiochemical purity of [F-18]4-PBFBP was more than 99%. The regional distribution of [F-18]4-PBFBP in mouse brain was also examined.

  DOI：

  10.1002/(sici)1099-1344(1998100)41:10<941::aid-jlcr151>3.0.co;2-6