6-chloro-1-cyclopropyl-8-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-morpholinyl)-4-oxo-3-quinolinecarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-1-cyclopropyl-8-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-morpholinyl)-4-oxo-3-quinolinecarboxylic acid
• 英文别名: 6-Chloro-1-cyclopropyl-7-(2,6-dimethylmorpholin-4-yl)-8-fluoro-4-oxo-quinoline-3-carboxylic acid；6-chloro-1-cyclopropyl-7-(2,6-dimethylmorpholin-4-yl)-8-fluoro-4-oxoquinoline-3-carboxylic acid
• 化学式: C₁₉H₂₀ClFN₂O₄
• 分子量: 394.83
• InChiKey: WGLILNHOEYEMKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-chloro-1-cyclopropyl-7,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 、 2,6-二甲基吗啉 、 1,2-二氮杂双环[2.2.2]辛烷 在 水 、 乙二醇甲醚 作用下， 以 二甲基亚砜 为溶剂， 反应 5.0h， 以1.6 g (41% of theory) of 6-chloro-1-cyclopropyl-8-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-morpholinyl)-4-oxo-3-quinoline-carboxylic acid of melting point 258-261° (with decomposition) is obtained的产率得到6-chloro-1-cyclopropyl-8-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-morpholinyl)-4-oxo-3-quinolinecarboxylic acid
  参考文献：
  名称：

  8-chloro-1-cyclopropyl-6,7-difluoro-1,

  摘要：

  本发明涉及公式（I）的7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧基-3-喹诺酸类化合物，其中X1，X2，R1和R2的含义如下所述。此外，本发明还涉及制备公式（I）化合物的方法以及含有它们的抗菌剂。

  公开号：

  US05468861A1

文献信息

• 2,4,5-Trihalogeno- and 2,3,4,5-tetrahalogenobenzene derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05200548A1

  公开（公告）日：1993-04-06

  2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO, R.sup.1 is H, Cl or F, and R.sup.2 is Cl or F, it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone caboxylic acids.

  化学式为##STR1##的2,4,5-三卤代苯衍生物，其中R为--COOH，--COCl，--COF，--CN，--CONH.sub.2，--CH.sub.2 OH，--CH.sub.2 Cl，--CHCl.sub.2，--CCl.sub.3或--CHO，R.sup.1为H，Cl或F，R.sup.2为Cl或F，仅当R.sup.1或R.sup.2为F时，其制备过程起始于苯甲腈与氟化钾反应。这些新化合物是类似喹诺酸类抗菌剂的中间体。
• 2,3,4,5-tetrahalogenobenzene derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05072038A1

  公开（公告）日：1991-12-10

  2,3,4,5-trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO, R.sup.1 is H, Cl or F, and R.sup.2 is Cl or F, it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.

  化学式为##STR1##的2,3,4,5-三卤代苯衍生物，其中R为--COOH，--COCl，--COF，--CN，--CONH.sub.2，--CH.sub.2 OH，--CH.sub.2 Cl，--CHCl.sub.2，--CCl.sub.3或--CHO，R.sup.1为H，Cl或F，R.sup.2为Cl或F，只有R.sup.1或R.sup.2可以是F，其制备过程始于苯甲腈与氟化钾反应。这些新化合物是喹诺酸类抗菌药物的中间体。
• 7-amino-1-cyclopropyl-6,8-dihalogeno-
  申请人：Bayer Aktiengesellschaft

  公开号：US05571812A1

  公开（公告）日：1996-11-05

  The invention is related to 7-amino-1-cyclopropyl-6,8- dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

  该发明涉及式(I)的7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧基-3-喹啉羧酸，其中X.sup.1，X.sup.2，R.sup.1和R.sup.2的含义如下所述。此外，该发明涉及制备式(I)化合物的过程以及含有它们的抗菌剂。
• 2,4,5-trihalogeno-and 2,3,4,5-tetrahalogenobenzene derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05565614A1

  公开（公告）日：1996-10-15

  2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## is which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO, R.sup.1 is H, Cl or F, and R.sup.2 is Cl or F, it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.

  公式为##STR1##的2,4,5-三卤代苯衍生物中，R为--COOH、--COCl、--COF、--CN、--CONH.sub.2、--CH.sub.2 OH、--CH.sub.2 Cl、--CHCl.sub.2、--CCl.sub.3或--CHO，R.sup.1为H、Cl或F，R.sup.2为Cl或F，仅可能为R.sup.1或R.sup.2为F，以苯甲腈为起始物与氟化钾反应制备它们的方法。这些新化合物是类似喹诺酸的抗菌剂的中间体。
• Process for the preparation of 3-chloro-2,4,5-trifluorobenzoyl chloride,
  申请人：Bayer Aktiengesellschaft

  公开号：US05362909A1

  公开（公告）日：1994-11-08

  2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO, R.sup.1 is H, Cl or F, and R.sup.2 is Cl or F, it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.

  公式为##STR1##的2,4,5-三卤代苯衍生物，其中R为--COOH，--COCl，--COF，--CN，--CONH.sub.2，--CH.sub.2OH，--CH.sub.2Cl，--CHCl.sub.2，--CCl.sub.3或--CHO，R.sup.1为H，Cl或F，R.sup.2为Cl或F，只有R.sup.1或R.sup.2可以是F，并且从苯甲腈与氟化钾反应开始的它们的制备过程。这些新化合物是类似于喹诺酸类抗菌剂的中间体。