melliferone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: melliferone
• 英文别名: (1S,4S,5R,8R,13S,14R,17S,18R)-4,5,9,9,13,20,20-heptamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-ene-10,23-dione
• 化学式: C₃₀H₄₄O₃
• 分子量: 452.678
• InChiKey: BHVMSBIGWPPGBF-LHAYROSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  33
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 sodium sulfate 作用下， 以 水 、 甲苯 为溶剂， 生成 3,11-dioxo-olean-12-en-28-oic acid 、 melliferone 、 liquidambaric lactone
  参考文献：
  名称：

  Practical Application of Oxidation Using a Novel Na₂WO₄−H₂O₂ System under Neutral Conditions for Scale-Up Manufacturing of 12α-Hydroxy-3-oxooleanano-28,13-lactone: Key Intermediate of Endothelin A Receptor Antagonist S-0139

  摘要：

  Novel alcohol oxidation using a Na2WO4-H2O2 System was applied to manufacture 12 alpha-hydroxy-3-oxooleanano-28,13-lactone which is it key intermediate of S-0139. Oxidation of the hydroxyl group of oleanolic acid was optimized based oil the design of experiment (DoE) approach. Statistical analysis was used to maximize the yield of the corresponding ketone and minimize the generation of byproducts. The safety evaluation of this oxidation was also conducted in detail, and pilot manufacturing was achieved.

  DOI：

  10.1021/op900265h

文献信息

• Oral compositions and use thereof
  申请人：——

  公开号：US20040057908A1

  公开（公告）日：2004-03-25

  The present invention relates to an oral composition which includes an organoleptically suitable carrier and an amount of a terpenoid and a flavonoid, dispersed in the carrier, which is effective to prevent or treat dental caries, dental plaque formation, gingivitis, candidiasis, dental stomatitis, aphthous ulceration, or fungal infection. The invention also relates to various uses of oral compositions, containing a terpenoid, a flavonoid, or both, such uses include: inhibiting the activity of surface-bound glusosyltransferase; treating or inhibiting dental caries, gingivitis, candidiasis, denture stomatitis; inhibiting the accumulation of microorganisms on an oral surface; and/or treating or inhibiting aphthous ulcerations on an oral surface.

  本发明涉及一种口服组合物，该组合物包括一种有机性适宜的载体以及一定量的萜类化合物和黄酮类化合物，它们分散在载体中，可有效预防或治疗龋齿、牙菌斑形成、牙龈炎、念珠菌病、牙齿口腔炎、口腔溃疡或真菌感染。本发明还涉及含有萜类化合物、类黄酮或两者的口服组合物的各种用途，这些用途包括：抑制表面结合的葡糖基转移酶的活性；治疗或抑制龋齿、牙龈炎、念珠菌病、义齿口腔炎；抑制微生物在口腔表面的积聚；和/或治疗或抑制口腔表面的阿弗他溃疡。
• ORAL COMPOSITIONS AND USE THEREOF
  申请人：University of Rochester

  公开号：EP1399119A2

  公开（公告）日：2004-03-24
• [EN] ORAL COMPOSITIONS AND USE THEREOF<br/>[FR] COMPOSITIONS A ADMINISTRATION ORALE ET LEURS APPLICATIONS
  申请人：UNIV ROCHESTER

  公开号：WO2002047615A2

  公开（公告）日：2002-06-20

  The present invention relates to an oral composition which includes an organoleptically suitable carrier and an amount of a terpenoid and a flavonoid, dispersed in the carrier, which is effective to prevent or treat dental caries, dental plaque formation, gingivitis, candidiasis, dental stomatitis, aphthous ulceration, or fungal infection. The invention also relates to various uses of oral compositions, containing a terpenoid, a flavonoid, or both, such uses include: inhibiting the activity of surface-bound glusosyltransferase; treating or inhibiting dental caries, gingivitis, candidiasis, denture stomatitis; inhibiting the accumulation of microorganisms on an oral surface; and/or treating or inhibiting aphthous ulcerations on an oral surface.