Monomethylaether des Asiatsaeuremethylesters | 23140-84-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Monomethylaether des Asiatsaeuremethylesters
• 英文别名: 2α.23-dihydroxy-3β-methoxy-ursen-(12)-oic acid-(28)-methyl ester；2α.23-Dihydroxy-3β-methoxy-ursen-(12)-saeure-(28)-methylester；methyl (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-11-hydroxy-9-(hydroxymethyl)-10-methoxy-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
• CAS: 23140-84-3
• 化学式: C₃₂H₅₂O₅
• 分子量: 516.762
• InChiKey: BOBKMOVMARCKQK-OHRISXMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 积雪草酸 在 tetrafluoroboric acid 、 乙醚 、 氯仿 作用下， 生成 Monomethylaether des Asiatsaeuremethylesters
  参考文献：
  名称：

  Polonsky; Zylber, Bulletin de la Societe Chimique de France, 1961, p. 1590

  摘要：

  DOI：

文献信息

• Polonsky, Bulletin de la Societe Chimique de France, 1952, p. 649,1015
  作者：Polonsky

  DOI：——

  日期：——
• Arthroscopic management of septic arthritis: stages of infection and results
  作者：Gordian Stutz、Markus S. Kuster、Frank Kleinstück、André Gächter

  DOI：10.1007/s001670000129

  日期：2000.9

  Seventy-six patients with septic arthritis (78 affected joints) were treated with a combination of arthroscopic irrigation, debridement, and antibiotic therapy according to the tested bacterial sensitivity. There were 62 knee, 10 shoulder, 5 ankle joints, and 1 hip joint. No antibiotics were added to the irrigating solution. The arthroscopic and radiological stage of infection, treatment, and outcome in these patients was analyzed. The patients were classified into three groups according to initial stage of joint infection (stage I: 21 patients, 22 joints; stage II: 43 patients, 44 joints; stage III: 12 patients, 12 joints). Causes of infection were: hematogenous dissemination in 54%, postoperative wound infection in 28% (17% after open, 11% after arthroscopic procedures). Other causes were: 10% intra-articular steroid injections, 3% diagnostic punctures, and 390 open traumatic injury of the joint. In 78% of the infected joints the causative organism could be identified: Staphylococcus aureus was the most common organism found (42%), followed by streptococci (15%), pneumococci (6%), Escherichia coli (4%), Staphylococcus epidemidis (3%), Borrelia burgdorferi, (3%), and others in 5%. In the stage I group only one patient needed repeated arthroscopic irrigation, in the stage II group 52%, and in the stage III group 75%. Open revision for eradication of the infection was necessary in one joint with stage II and in two joints with stage III infection (3%). Two joints of the stage III group needed additional surgery after successful treatment of the infection. The combination of arthroscopic irrigation and systemic antibiotic therapy was able to cure 91% of the affected joints. Open revision was necessary in 4% of joints. The number of arthroscopic procedures and the efficacy of treatment depended on the initial stage of the infection. It is concluded that an arthroscopic staging of the initial joint infection has prognostic and therapeutic consequences.
• Polonsky; Zylber, Bulletin de la Societe Chimique de France, 1961, p. 1590
  作者：Polonsky、Zylber

  DOI：——

  日期：——