3-ethyl-4-[(E)-9-hydroxy-4,6,8,10-tetramethyl-7-oxododec-4-en-2-yl]oxetan-2-one | 76808-15-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-ethyl-4-[(E)-9-hydroxy-4,6,8,10-tetramethyl-7-oxododec-4-en-2-yl]oxetan-2-one
• CAS: 76808-15-6
• 化学式: C₂₁H₃₆O₄
• 分子量: 352.5
• InChiKey: UNBMQQNYLCPCHS-ZRDIBKRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• WGK Germany：
  3
• RTECS号：
  RQ7720000

文献信息

• INHIBITORS OF POLYISOPRENYLATED METHYLATED PROTEIN METHYL ESTERASE
  申请人：Lamango Nazarius Saah

  公开号：US20090253640A1

  公开（公告）日：2009-10-08

  Inhibitors of the enzyme prenylated methylated protein methyl esterase (PMPMEase), the last step in the prenylation process for many eukaryotic proteins, having the general structure R 1 -X-A-B(R 2 )-Y or R 1 -X-A(R 2 )-B-Y, where R 1 is preferably a polyisoprenyl group, X is a linking group, Y is a group that promotes affinity interactions to the active site of PMPMEase and imparts hydrolysis resistance to the inhibitor, A and B are bridge atoms, and R 2 is a characteristic-providing substituent.

  抑制酶前醇基化蛋白甲基酯酶（PMPMEase）的化合物，这是许多真核蛋白质前醇化过程的最后一步，具有一般结构R1-X-A-B（R2）-Y或R1-X-A（R2）-B-Y，其中R1最好是多异戊烯基团，X是连接基团，Y是促进与PMPMEase活性位点的亲和作用并赋予抑制剂水解抗性的基团，A和B是桥接原子，R2是提供特征的取代基。
• Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury
  申请人：Vinten-Johansen Jakob

  公开号：US20060205671A1

  公开（公告）日：2006-09-14

  Methods and compositions including combined use of a serine protease inhibitor and adenosine when administered as a single pharmaceutical composition, concomitantly or sequentially in any order to a living subject for preventing organ ischemia or reperfusion injury. The methods and compositions disclosed herein can be used in such procedures as cardiac surgery, non-surgical cardiac revascularization, organ transplantation, perfusion, ischemia, reperfusion, ischemia-reperfusion injury, oxidant injury, cytokine induced injury, shock induced injury, resuscitations injury or apoptosis.
• US7897604B2
  申请人：——

  公开号：US7897604B2

  公开（公告）日：2011-03-01
• US8097722B2
  申请人：——

  公开号：US8097722B2

  公开（公告）日：2012-01-17