2α,19α-dihydroxy-3-oxo-urs-12-en-28-oic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2α,19α-dihydroxy-3-oxo-urs-12-en-28-oic acid
• 英文别名: 2alpha,19alpha-Dihydroxy-3-oxo-12-ursen-28-oic acid；(1R,2R,4aS,6aR,6aS,6bR,8aR,11R,12aR,14bS)-1,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-3,4,5,6,6a,7,8,8a,11,12,13,14b-dodecahydro-2H-picene-4a-carboxylic acid
• 化学式: C₃₀H₄₆O₅
• 分子量: 486.692
• InChiKey: LJORXTIGOHMBOS-OTRVPSFMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  35
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• ACCELERATOR FOR INITIAL INSULIN SECRETION
  申请人：Use-Techno Corporation

  公开号：EP1674089A1

  公开（公告）日：2006-06-28

  The present invention provides an early insulin secretion stimulator consisting of a triterpene represented by the following general formula (1) and/or a triterpene represented by the following general formula (2). [where R1 represents COOH, etc., R11 and R12 represent CH2OH, etc., X1 represents hydrogen or OH and X11, X12, X21 and X22 represent OH, etc.]

  本发明提供了一种早期胰岛素分泌刺激剂，由以下通式（1）代表的三萜和/或以下通式（2）代表的三萜组成。 [其中 R1 代表 COOH 等，R11 和 R12 代表 CH2OH 等，X1 代表氢或 OH，X11、X12、X21 和 X22 代表 OH 等。］
• Method for producing triterpene composition
  申请人：Matsuyama Futoshi

  公开号：US20050255569A1

  公开（公告）日：2005-11-17

  The present invention provides a method of producing a triterpene composition wherein callus induced from banaba, loquat, perilla or guava is cultured with indoleacetic acid and another plant hormone, and a triterpene composition containing at least one selected from the group consisting of corosolic acid, tormentic acid, 2α,19α-dihydroxy-3-oxo-urs-12-en-28-oic acid and maslinic acid is obtained from the cultured callus.

  本发明提供了一种生产三萜组合物的方法，其中用吲哚乙酸和另一种植物激素培养从芭蕉、枇杷、紫苏或番石榴诱导的胼胝体，并从培养的胼胝体中获得一种三萜组合物，该组合物含有至少一种选自珊瑚olic酸、tormentic acid、2α,19α-dihydroxy-3-oxo-urs-12-en-28-oic acid 和 maslinic acid 组成的组。
• Organic extract of geum japonicum thunb variant and use thereof
  申请人：Li Ming

  公开号：US20060134229A1

  公开（公告）日：2006-06-22

  An organic extract of a Chinese herbal medicine Geum Japonicum thunb var. has been identified that displayed potent stimulatory effects on rapid agiogenesis (<24 h), myogenesis and blocking fibrosis in traumatized skeletal muscles. The extract has displayed potent dual effects on angiogenesis and myogenesis in damaged skeletal muscles leading to complete skeletal muscle healing in rabbit and rat animal models. The extract of the present invention can be developed into an effective therapeutic drug for the treatment of skeletal muscle trauma, soft tissue healing including burn, skin wound and operation cut, and bone fracture and defect healings.

  研究发现，一种中药材Geum Japonicum thunb var.的有机提取物对创伤骨骼肌的快速血管生成（<24小时）、肌生成和阻断纤维化具有强大的刺激作用。本发明提取物对受损骨骼肌的血管生成和肌生成具有强效的双重作用，可导致兔和大鼠动物模型中骨骼肌的完全愈合。本发明的提取物可开发成一种有效的治疗药物，用于治疗骨骼肌创伤、软组织愈合（包括烧伤、皮肤伤口和手术切口）以及骨折和缺损愈合。
• AN ORGANIC EXTRACT OF GEUM JAPONICUM THUMB VARIANT AND USE THEREOF
  申请人：THE CHINESE UNIVERSITY OF HONG KONG

  公开号：EP1569668A1

  公开（公告）日：2005-09-07
• EP1569668A4
  申请人：——

  公开号：EP1569668A4

  公开（公告）日：2009-07-01

表征谱图