1-(N-imidazolyl-acetyl)-4-cyclohexyl-benzene | 73931-84-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(N-imidazolyl-acetyl)-4-cyclohexyl-benzene
• 英文别名: Ethanone, 1-(4-cyclohexylphenyl)-2-(1H-imidazol-1-yl)-；1-(4-cyclohexylphenyl)-2-imidazol-1-ylethanone
• CAS: 73931-84-7
• 化学式: C₁₇H₂₀N₂O
• 分子量: 268.359
• InChiKey: YAEMCNDAIHEJGL-UHFFFAOYSA-N

物化性质

• 熔点：
  132-133 °C(Solv: benzene (71-43-2))
• 沸点：
  490.9±38.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(N-imidazolyl-acetyl)-4-cyclohexyl-benzene 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以54%的产率得到1-[1'-hydroxy-2'-(N-imidazolyl)-ethyl]-4-cyclohexyl-benzene
  参考文献：
  名称：

  Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(.omega.-phenyl-.omega.-hydroxyalkyl)imidazoles

  摘要：

  A novel series of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[beta-[4-(beta-phenylethyl)phenyl]-beta-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.

  DOI：

  10.1021/jm00138a017
• 作为产物：
  描述：

  环己基苯 在 三氯化铝 作用下， 以 二硫化碳 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成 1-(N-imidazolyl-acetyl)-4-cyclohexyl-benzene
  参考文献：
  名称：

  Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(.omega.-phenyl-.omega.-hydroxyalkyl)imidazoles

  摘要：

  A novel series of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[beta-[4-(beta-phenylethyl)phenyl]-beta-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.

  DOI：

  10.1021/jm00138a017

文献信息

• Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System
  申请人：Gupta Ajay

  公开号：US20110319459A1

  公开（公告）日：2011-12-29

  Disclosed are compounds of the general formula (I): TC n D  (I), compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods useful for treating or preventing cancer and for inhibiting tumour tissue growth. These compounds attenuate the oxidative damage associated with increased heme-oxygenase activity and can reduce cell proliferation in transformed cells. In addition, the described compounds and compositions are useful as neuroprotectants and for treating or preventing neurodegenerative disorders and other diseases of the central nervous system.

  本发明涉及一般式（I）的化合物：TCnD（I），包括单独使用或与其他化疗药物联合使用的有效量的该化合物的组合物，以及用于治疗或预防癌症和抑制肿瘤组织生长的有用方法。这些化合物减弱了与增加血红素氧合酶活性相关的氧化损伤，并可以减少转化细胞中的细胞增殖。此外，所述化合物和组合物可用作神经保护剂，并用于治疗或预防中枢神经系统的神经退行性疾病和其他疾病。
• NARDI, D.;TAJANA, A.;LEONARDI, A.;PENNINI, R.;PORTIOLI, F.;MAGISTRETTI, M+, J. MED. CHEM., 1981, 24, N 6, 727-731
  作者：NARDI, D.、TAJANA, A.、LEONARDI, A.、PENNINI, R.、PORTIOLI, F.、MAGISTRETTI, M+

  DOI：——

  日期：——
• US4275071A
  申请人：——

  公开号：US4275071A

  公开（公告）日：1981-06-23
• US4246274A
  申请人：——

  公开号：US4246274A

  公开（公告）日：1981-01-20
• US4301166A
  申请人：——

  公开号：US4301166A

  公开（公告）日：1981-11-17