5-乙基吡咯烷-2,4-二酮 | 74730-37-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-乙基吡咯烷-2,4-二酮
• 英文名称: 5-ethyl-pyrrolidine-2,4-dione
• 英文别名: 5-ethyl-2,4-pyrrolidinedione；5-Ethylpyrrolidine-2,4-dione
• CAS: 74730-37-3
• 化学式: C₆H₉NO₂
• mdl: MFCD19219239
• 分子量: 127.143
• InChiKey: KBOXRYOLOVHXHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3aS)-5c-((1R,2E,4E)-5-chlorocarbonyl-1,3-dimethyl-penta-2,4-dienyl)-2c,6t,9a-trimethyl-8-oxo-(9at)-octahydro-3ar,7c-epioxido-furo[3,2-b]oxocine-3c-carboxylic acid methyl ester 、 5-乙基吡咯烷-2,4-二酮 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (3aS)-5c-[(1R,2E,4E)-6-((3E,5Ξ)-5-ethyl-2,4-dioxo-pyrrolidin-3-ylidene)-6-hydroxy-1,3-dimethyl-hexa-2,4-dienyl]-2c,6t,9a-trimethyl-8-oxo-(9at)-octahydro-3ar,7c-epioxido-furo[3,2-b]oxocine-3c-carboxylic acid methyl ester
  参考文献：
  名称：

  Nakagawa,S. et al., Heterocycles, 1979, vol. 13, p. 477 - 495

  摘要：

  DOI：

文献信息

• Method for reducing a susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof
  申请人：Brown R. Truman

  公开号：US20060089316A1

  公开（公告）日：2006-04-27

  Disclosed are methods of using various compounds, which are known to bind to 3-deoxyglucosone (3DG) or precursors thereof, in order to reduce a susceptibility to tumor formation and/or to prevent or delay onset of tumor formation induced by 3DG and its precursors. Also disclosed is the reduction of 3DG levels in high fructose corn syrop so that the high fructose corn syrup is less likely to induce tumor formation.

  公开了使用各种已知与3-脱氧葡萄糖酮（3DG）或其前体结合的化合物的方法，以减少对肿瘤形成的易感性和/或预防或延迟由3DG及其前体诱导的肿瘤形成。还公开了降低高果糖玉米糖浆中3DG水平的方法，以使高果糖玉米糖浆不太可能诱导肿瘤形成。
• 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES
  申请人：Galley Guido

  公开号：US20110144333A1

  公开（公告）日：2011-06-16

  The invention relates to compounds of formula I wherein R 1 , R 2 , X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also provides pharmaceutical compositions and methods of manufacture of such compounds. The compounds are useful for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

  本发明涉及化合物I的配方，其中R1、R2、X、Y和n在规范中定义，并涉及其药学上可接受的酸盐。本发明还提供了这些化合物的制药组合物和制造方法。这些化合物可用于治疗与微量胺相关受体的生物功能相关的疾病，这些疾病包括抑郁症、焦虑症、双相情感障碍、注意力缺陷多动障碍、压力相关障碍、精神疾病、精神分裂症、神经系统疾病、帕金森病、神经退行性疾病、阿尔茨海默病、癫痫、偏头痛、物质滥用和代谢性疾病、饮食失调、糖尿病、糖尿病并发症、肥胖症、血脂异常、能量消耗和吸收障碍、体温稳态障碍和功能失调、睡眠和昼夜节律障碍以及心血管疾病。
• BILE ACID ANALOGS AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US20160145296A1

  公开（公告）日：2016-05-26

  The present invention relates to compounds of Formula (IA) and Formula (IB), and pharmaceutically acceptable salts thereof, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and m are as defined herein, pharmaceutical compositions comprising these compounds and methods of use of these compounds for treating a TGR5 mediated disease or condition.
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.
• US5534540A
  申请人：——

  公开号：US5534540A

  公开（公告）日：1996-07-09