4-ethoxy-5-fluoropyridin | 924862-33-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-ethoxy-5-fluoropyridin
• 英文别名: 4-Ethoxy-3-fluoropyridine
• CAS: 924862-33-9
• 化学式: C₇H₈FNO
• mdl: MFCD01646175
• 分子量: 141.145
• InChiKey: HHIZEIJXMGDVHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-ethoxy-5-fluoropyridin 在 lithium diisopropyl amide 、 硼酸三甲酯 、 过氧乙酸 作用下， 以 四氢呋喃 、 溶剂黄146 为溶剂， 反应 23.0h， 生成 4-ethoxy-3-fluoropyridin-2-ol
  参考文献：
  名称：

  Design and synthesis of fluorine-substituted 3-hydroxypyridin-4-ones

  摘要：

  The presence of fluorine in an organic molecule can dramatically alter its chemical and biological properties due to its unique characteristics. Several 2- and 5-fluorine-substituted 3-hydroxypyridin-4-ones have been synthesised with the intention of improving the pharmaceutical profile of deferiprone. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.134

文献信息

• Design and synthesis of fluorine-substituted 3-hydroxypyridin-4-ones
  作者：Yong Min Ma、Robert C. Hider

  DOI：10.1016/j.tetlet.2010.07.134

  日期：2010.10

  The presence of fluorine in an organic molecule can dramatically alter its chemical and biological properties due to its unique characteristics. Several 2- and 5-fluorine-substituted 3-hydroxypyridin-4-ones have been synthesised with the intention of improving the pharmaceutical profile of deferiprone. (C) 2010 Elsevier Ltd. All rights reserved.