1,4-bis(1-(7-ethyl-1H-indol-3-yl)-2-nitroethyl)benzene | 1246172-01-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1,4-bis(1-(7-ethyl-1H-indol-3-yl)-2-nitroethyl)benzene
• 英文别名: 7-ethyl-3-[1-[4-[1-(7-ethyl-1H-indol-3-yl)-2-nitroethyl]phenyl]-2-nitroethyl]-1H-indole
• CAS: 1246172-01-9
• 化学式: C₃₀H₃₀N₄O₄
• 分子量: 510.593
• InChiKey: NJTLEDSBLVDGRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-乙基吲哚 、 1,4-bis(2-nitrovinyl)benzene 反应 8.0h， 以71%的产率得到1,4-bis(1-(7-ethyl-1H-indol-3-yl)-2-nitroethyl)benzene
  参考文献：
  名称：

  Catalyst free conjugate addition of indoles and pyrroles to nitro alkenes under solvent free condition (SFC): an effective greener route to access 3-(2-nitro-1-phenylethyl)-1H-indole and 2-(2-nitro-1-phenylethyl)-1H-pyrrole derivatives

  摘要：

  Catalyst free conjugate addition of reactive hetero aromatics (pyrrole and indoles) to nitro alkenes under solvent free condition is described. This method provides several advantages, such as operational simplicity, solvent-free conditions and good yields of products. Also it is environmentally friendly and more cost effective alternative to existing protocols. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.05.104

文献信息

• Catalyst free conjugate addition of indoles and pyrroles to nitro alkenes under solvent free condition (SFC): an effective greener route to access 3-(2-nitro-1-phenylethyl)-1H-indole and 2-(2-nitro-1-phenylethyl)-1H-pyrrole derivatives
  作者：Pateliya Mujjamil Habib、Veerababurao Kavala、Chun-Wei Kuo、Mustafa J. Raihan、Ching-Fa Yao

  DOI：10.1016/j.tet.2010.05.104

  日期：2010.8

  Catalyst free conjugate addition of reactive hetero aromatics (pyrrole and indoles) to nitro alkenes under solvent free condition is described. This method provides several advantages, such as operational simplicity, solvent-free conditions and good yields of products. Also it is environmentally friendly and more cost effective alternative to existing protocols. (C) 2010 Elsevier Ltd. All rights reserved.