Isrib | 1597403-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Isrib
• 英文别名: 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
• CAS: 1597403-47-8
• 化学式: C₂₂H₂₄Cl₂N₂O₄
• 分子量: 451.3
• InChiKey: HJGMCDHQPXTGAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Modulators of the eIF2alpha pathway
  申请人：The Regents of the University of California

  公开号：US10343981B2

  公开（公告）日：2019-07-09

  Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.

  本文提供的化合物和方法主要用于调节 eIF2α 磷酸化、综合应激反应（ISR）和未折叠蛋白反应（UPR）的翻译效应；治疗疾病；增加蛋白质产量以及改善长期记忆。
• Treatment for glaucoma and other eye diseases
  申请人：University of North Texas Health Science Center at Fort Worth

  公开号：US10774328B2

  公开（公告）日：2020-09-15

  The present invention includes a composition and method for the treatment of an eye disease comprising a therapeutically effective amount of an autophagy stimulator that treats or slows the progression of the eye disease by enhancing or stimulating autophagy or correcting an autophagy deficiency.

  本发明包括一种用于治疗眼疾的组合物和方法，其中含有治疗有效量的自噬刺激物，通过增强或刺激自噬或纠正自噬缺陷来治疗或减缓眼疾的进展。
• CELL STABILIZATION
  申请人：Biomatrica, Inc.

  公开号：EP3007556A2

  公开（公告）日：2016-04-20
• NOVEL METHODS OF TREATING HEARING LOSS
  申请人：The Regents of the University of California

  公开号：EP3368037A1

  公开（公告）日：2018-09-05
• MODULATORS OF THE EIF2ALPHA PATHWAY
  申请人：The Regents of the University of California

  公开号：US20160096800A1

  公开（公告）日：2016-04-07

  Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.