5-氨基-2-羟基-3-磺基苯甲酸 | 6201-87-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氨基-2-羟基-3-磺基苯甲酸
• 英文名称: 5-amino-2-hydroxy-3-sulfobenzoic acid
• 英文别名: 5-Amino-3-sulfosalicylic acid
• CAS: 6201-87-2
• 化学式: C₇H₇NO₆S
• mdl: MFCD00024945
• 分子量: 233.202
• InChiKey: MLPWLRUWQJVULT-UHFFFAOYSA-N

物化性质

• 物理描述：
  5-amino-3-sulfosalicylic acid is a brown powder. (NTP, 1992)
• 溶解度：
  less than 1 mg/mL at 66° F (NTP, 1992)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  146
• 氢给体数：
  4
• 氢受体数：
  7

安全信息

• 海关编码：
  2922509090

反应信息

• 作为反应物：
  描述：

  5-氨基-2-羟基-3-磺基苯甲酸 生成 三溴苯酚
  参考文献：
  名称：

  The Piria Reaction. III.¹ Mechanism Studies²

  摘要：

  DOI：

  10.1021/ja01293a011
• 作为产物：
  描述：

  5-氨基水杨酸 在 硫酸 作用下， 生成 5-氨基-2-羟基-3-磺基苯甲酸
  参考文献：
  名称：

  Hirve, Journal of the Indian Chemical Society, 1930, vol. 7, p. 894

  摘要：

  DOI：

文献信息

• Structure-activity relationship studies with symmetric naphthalenesulfonic acid derivatives. Synthesis and influence of spacer and naphthalenesulfonic acid moiety on anti-HIV-1 activity
  作者：Prem Mohan、Man Fai Wong、Sandeep Verma、Peggy P. Huang、Anura Wickramasinghe、Masanori Baba

  DOI：10.1021/jm00066a008

  日期：1993.7

  Symmetric bis(naphthalenesulfonic acid) derivatives containing a variety of spacers have been synthesized and evaluated for anti-HIV-1 activity in four assay systems. In the assay that measured inhibition of HIV-1-induced cytopathogenicity using a laboratory strain (HTLV-IIIB), a hexamethylene and octamethylene spacer derivative of 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid emerged as the most potent

  合成了含有多种间隔基的对称双（萘磺酸）衍生物，并在四种测定系统中评估了其抗HIV-1活性。在使用实验室菌株（HTLV-IIIB）测定对HIV-1诱导的细胞致病性抑制作用的测定中，最有效的衍生物是4-氨基-5-羟基-2,7-萘二磺酸的六亚甲基和八亚甲基间隔衍生物。六亚甲基间隔类似物的体外治疗指数> 120。在巨细胞形成试验中测试了选定的衍生物。在该测定中，最有效的衍生物还是六亚甲基化合物。针对HIV-1（HE株）的临床分离株对所选衍生物的评估表明，六亚甲基衍生物是最有效的化合物。在测定抑制人类外周血淋巴细胞中HIV-1诱导的细胞病变的实验中，六亚甲基化合物以最活跃的衍生物形式出现，显示50％的抑制浓度为1.3 microM。这些研究清楚地表明，某些萘磺酸基团与特定的间隔基偶联时，在无毒浓度下可产生抗HIV-1活性。在4-氨基-5-羟基-2，7-萘二磺酸系列中，间隔物长度的缩短，优选具有柔性聚
• Polyhydroxyalkanoate having vinyl group, ester group, carboxyl group, and sulfonic group, and method of producing the same
  申请人：Kenmoku Takashi

  公开号：US20070073006A1

  公开（公告）日：2007-03-29

  To provide a novel polyhydroxyalkanoate having a reactive functional group in a molecule and a method of producing the same; and a novel polyhydroxyalkanoate having a new function obtained by chemically modifying the polyhydroxyalkanoate having a reactive functional group and a method of producing the same. By utilizing a vinyl group of a polyhydroxyalkanoate containing a unit having the vinyl group at a side chain thereof, a polyhydroxyalkanoate containing units having a carboxyl group, an amide group, and a sulfonic group in a molecule is induced.

  提供一种分子中具有反应性功能基团的新型聚羟基脂肪酸酯及其制备方法；以及通过化学修饰具有反应性功能基团的聚羟基脂肪酸酯获得的具有新功能的新型聚羟基脂肪酸酯及其制备方法。通过利用聚羟基脂肪酸酯中含有侧链上乙烯基的单元的乙烯基，诱导聚羟基脂肪酸酯中含有羧基、酰胺基和磺酸基的单元。
• Polyhydroxyalkanoic Acid Having Vinyl, Ester, Carboxyl or Sulfonic Acid Group and Producing Method Therefor
  申请人：Kenmoku Takashi

  公开号：US20080064828A1

  公开（公告）日：2008-03-13

  The invention is to provide a novel polyhydroxyalkanoate having a reactive function group within the molecule and a producing method therefor In a polyhydroxyalkanoate containing a unit having a vinyl group in a side chain, such vinyl group is utilized for deriving a polyhydroxyalkanoate comprising a carboxyl group or a unit having an amide group and a sulfonic acid group.

  本发明旨在提供一种新型聚羟基烷酸酯，其分子内具有反应性功能团，并提供其制备方法。在含有侧链中具有乙烯基团的聚羟基烷酸酯中，利用该乙烯基团来获得含有羧基或含有酰胺基和磺酸基的聚羟基烷酸酯。
• Polyhydroxyalkanoate having vinyl group, ester group, carboxyl group and sulfonic acid group, and production method thereof
  申请人：Kenmoku Takashi

  公开号：US20060247414A1

  公开（公告）日：2006-11-02

  A novel polyhydroxyalkanoate having a reactive functional group in a molecule, and a production method thereof, etc. are provided. By utilizing the vinyl group of polyhydroxyalkanoate which contains a unit having a vinyl group on a side chain, a polyhydroxyalkanoate which contains a carboxyl group and a unit having an amide group and a sulfonic acid group in a molecule is derived.

  提供了一种具有反应性功能基团的新型聚羟基脂肪酸酯及其制备方法等。通过利用聚羟基脂肪酸酯中含有侧链上具有乙烯基的单元的乙烯基，可以得到一种在分子中含有羧基和酰胺基以及磺酸基的单元的聚羟基脂肪酸酯。
• ANION-EXCHANGE DISPLACEMENT CHROMATOGRAPHY PROCESS AND ANIONIC ORGANIC COMPOUNDS FOR USE AS DISPLACER COMPOUNDS IN ANION-EXCHANGE DISPLACEMENT CHROMATOGRAPHY PROCESS
  申请人：Little Charles

  公开号：US20070125712A1

  公开（公告）日：2007-06-07

  A displacement chromatography process, including: loading onto a stationary phase comprising an anion-exchange material a mixture comprising one or more component to be separated; displacing at least one of the one or more component from the stationary phase by applying to the stationary phase a mixture comprising an polyaromatic polyanionic displacer compound having a general formula Cen (Ar) w , in which Cen is a central bond or group, Ar is an aromatic nucleus, w=2 to the maximum number of sites one Cen, and Ar is substituted with a plurality of An − , in which each An − is independently defined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar is further substituted with a plurality of G, in which G is defined as independently H, C 1 -C 6 alkyl, halogen, nitro, hydroxy, C 1 -C 6 alkoxy In addition, a group of polyaromatic polyanionic displacer compounds useful in the process is disclosed.

  一种位移层析过程，包括：将待分离的一个或多个组分的混合物加载到包含一种阴离子交换材料的静态相中；通过施加一种由聚芳香族聚阴离子位移剂化合物组成的混合物，其中该位移剂化合物具有通式Cen（Ar）w，其中Cen是中心键或基团，Ar是芳香族核，w为2到Cen上最大位点数，Ar被多个An-取代，其中每个An-独立定义为磺酸盐，羧酸盐，膦酸盐，磷酸盐，硫酸盐；并且Ar还被多个G取代，其中G被定义为独立的H，C1-C6烷基，卤素，硝基，羟基，C1-C6烷氧基。此外，还公开了一组在该过程中有用的聚芳香族聚阴离子位移剂化合物。