3-(Dimethylamino)-1-(furan-3-yl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(Dimethylamino)-1-(furan-3-yl)prop-2-en-1-one
• 化学式: C₉H₁₁NO₂
• 分子量: 165.19
• InChiKey: JYNBBGZIKXUJAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  33.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(Dimethylamino)-1-(furan-3-yl)prop-2-en-1-one 、 4-甲基-1H-吡唑-3-胺 以 溶剂黄146 为溶剂， 反应 6.0h， 生成 3-Methyl-7-(furan-3-yl)pyrazolo[1,5-a]pyrimidine
  参考文献：
  名称：

  Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic

  摘要：

  本公开说明了具有抗焦虑活性的取代嘧唑并[1,5-a]嘧啶。

  公开号：

  US04281000A1
• 作为产物：
  描述：

  1-呋喃-3-乙酮 、 N,N-二甲基甲酰胺 在 正己烷 作用下， 反应 16.0h， 以to give 3-dimethylamino-1-(3-furyl)-2-propen-1-one的产率得到3-(Dimethylamino)-1-(furan-3-yl)prop-2-en-1-one
  参考文献：
  名称：

  Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic

  摘要：

  本公开说明了具有抗焦虑活性的取代嘧唑并[1,5-a]嘧啶。

  公开号：

  US04281000A1

文献信息

• 6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists
  申请人：Briner Karin

  公开号：US20080214520A1

  公开（公告）日：2008-09-04

  The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: Formula (I) where: R 6 is selected from the group consisting of (a, b, c, d, e) and other substituents are as defined in the specification.

  本发明提供了Formula I的6-取代的2,3,4,5-四氢-1H-苯并[d]氮杂环庚烯作为选择性5-HT2C受体激动剂，用于治疗与5-HT2C相关的疾病，包括肥胖症、强迫症、抑郁症和焦虑症：Formula (I)其中：R6选自(a、b、c、d、e)等基团组成的群，其他取代基如规范中定义。
• .alpha.,.beta.-Unsaturated ketones and aldehydes and method of
  申请人：Eli Lilly and Company

  公开号：US04175087A1

  公开（公告）日：1979-11-20

  .alpha.,.beta.-Unsaturated ketones and aldehydes, together with a method of preparation thereof which comprises reacting aldehydes and cyclic and acyclic ketones possessing a methyl or methylene group .alpha.- to the carbonyl function with N,N-dialkylformamide dialkyl acetal to yield the corresponding enaminoketones and enaminoaldehydes, which enaminoketones and enaminoaldehydes are allowed to react with alkyllithium reagents to yield the corresponding nitrogen-free 2-alkylidene ketones and 2-alkylidene aldehydes.

  本发明涉及.alpha.，.beta.-不饱和酮和醛，以及其制备方法，其包括将具有甲基或亚甲基基团的环状和非环状酮和醛与N，N-二烷基甲酰胺二烷基缩醛反应，以产生相应的烯胺酮和烯胺醛，然后将这些烯胺酮和烯胺醛与烷基锂试剂反应，以产生相应的无氮2-烷基亚甲基酮和2-烷基亚甲基醛。
• 4-Heteroarylimidazo-[1,5-A]pyrimidines
  申请人：American Cyanamid Company

  公开号：US04374988A1

  公开（公告）日：1983-02-22

  Novel pyrimidine compounds are disclosed of the class represented by the formula: ##STR1## wherein R.sub.1 is selected from the class consisting essentially of hydrogen, chloro, bromo, cyano (--CN), carbamoyl (--CO--NH.sub.2), carboxyl (--COOH), and lower alkoxycarbonyl (--CO--O--R.sub.3, where R.sub.3 is a lower alkyl radical having 1-4 carbon atoms), and wherein R.sub.2 is a monovalent radical selected from the class consisting essentially of furyl, thienyl, 3-pyridyl and 3-pyridyl-N-oxide, either of said pyridyl radicals optionally being substituted with an alkyl radical having from 1 to 4 carbon atoms. Processes of preparing such compounds are disclosed. The novel compounds are useful as anxiolytic agents in ameliorating anxiety in a mammal.

  本发明揭示了一类新型嘧啶化合物，其代表式为：##STR1## 其中R.sub.1选自本质上由氢、氯、溴、氰(-CN)、氨基甲酰(-CO-NH.sub.2)、羧基(-COOH)和低碳基醇酸酯(-CO-O-R.sub.3，其中R.sub.3是具有1-4个碳原子的低碳基基团)组成的类别，R.sub.2是选自本质上由呋喃基、噻吩基、3-吡啶基和3-吡啶基-N-氧化物的一价基团，其中所述的吡啶基团可选择地被取代为具有1至4个碳原子的烷基基团。本发明还揭示了制备这类化合物的方法。这些新型化合物可用作抗焦虑剂，用于改善哺乳动物的焦虑症状。
• Substituted pyrazolo (1,5-a) pyrimidines, and their preparation
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0025819A1

  公开（公告）日：1981-04-01

  Compoundsoftheformula: wherein R1 is hydrogen or alkyl having from 1 to 3 carbon atoms; R2 is selected from the group consisting of wherein R' is hydrogen or alkyl having from 1 to 3 carbon atoms; R3 is hydrogen, fluoro, chloro, bromo, cyano, cyanomethyl, carbamoyl or alkyl having from 1 to 3 carbon atoms; R4 is selected from the group consisting of hydrogen, fluoro, chloro, bromo, formyl, carboxyl, cyano, hydroxymethyl, N-hydroxyformimidoyl, alkyl having from 1 to 3 carbon atoms and moieties of the formulae: where R is alkyl having from 1 to 3 carbon atoms, and the pharmacologically acceptable acid-addition salts thereof, possess anxiolytic activity.

  其中 R1 为氢或具有 1 至 3 个碳原子的烷基；R2 选自以下组成的组：其中 R' 为氢或具有 1 至 3 个碳原子的烷基；R3 为氢、氟、氯、溴、氰基、氰基甲基、氨基甲酰基或具有 1 至 3 个碳原子的烷基；R4 选自以下组成的组：氢、氟、氯、溴、甲酰基、羧基、氰基、羟甲基、N-羟基甲酰亚胺基、具有 1 至 3 个碳原子的烷基和以下式子的分子：其中 R 为具有 1 至 3 个碳原子的烷基及其药理上可接受的酸加成盐，具有抗焦虑活性。
• 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1924578B1

  公开（公告）日：2013-11-06