1-Benzoyl-2-methyl-1,2-dihydrochinolin | 36022-93-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Benzoyl-2-methyl-1,2-dihydrochinolin
• 英文别名: (2-methyl-2H-quinolin-1-yl)-phenylmethanone
• CAS: 36022-93-2
• 化学式: C₁₇H₁₅NO
• 分子量: 249.312
• InChiKey: MAKBLQVIBFPTMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Benzoyl-2-methyl-1,2-dihydrochinolin 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以68%的产率得到1-benzoyl-3,4-epoxy-2-methyl-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  1-Acyl-2-alkyl-3,4-epoxy-1,2,3,4-tetrahydroquinolines — Synthesis and Reactions with N-Nucleophiles

  摘要：

  Epoxide opening of the title compounds (6) with primary or secondary amines using lithium perchlorate as catalyst gave 1,2,3,4-tetrahydroquinolines with stereochemically well defined substitution pattern in the piperidine moiety (7,8). By-products (9,10), formed by acyl migration, were observed.

  DOI：

  10.3987/com-94-6677
• 作为产物：
  描述：

  2-methyl-1,2-dihydroquinoline 、 苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到1-Benzoyl-2-methyl-1,2-dihydrochinolin
  参考文献：
  名称：

  1-Acyl-2-alkyl-3,4-epoxy-1,2,3,4-tetrahydroquinolines — Synthesis and Reactions with N-Nucleophiles

  摘要：

  Epoxide opening of the title compounds (6) with primary or secondary amines using lithium perchlorate as catalyst gave 1,2,3,4-tetrahydroquinolines with stereochemically well defined substitution pattern in the piperidine moiety (7,8). By-products (9,10), formed by acyl migration, were observed.

  DOI：

  10.3987/com-94-6677

文献信息

• 1-Acyl-2-alkyl-3,4-epoxy-1,2,3,4-tetrahydroquinolines — Synthesis and Reactions with N-Nucleophiles
  作者：Martin Kratzel、Romana Hiessböck

  DOI：10.3987/com-94-6677

  日期：——

  Epoxide opening of the title compounds (6) with primary or secondary amines using lithium perchlorate as catalyst gave 1,2,3,4-tetrahydroquinolines with stereochemically well defined substitution pattern in the piperidine moiety (7,8). By-products (9,10), formed by acyl migration, were observed.