1-chloro-3-l-menthoxypropan-2-ol | 1164152-78-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-chloro-3-l-menthoxypropan-2-ol
• 英文别名: 1-Chloro-3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropan-2-ol
• CAS: 1164152-78-6
• 化学式: C₁₃H₂₅ClO₂
• 分子量: 248.793
• InChiKey: PYUZDZAASJRLCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Method for producing 3-l-menthoxypropane-1,2-diol
  申请人：Takasago International Corporation

  公开号：US20020156327A1

  公开（公告）日：2002-10-24

  A method for safely and efficiently producing high purity 3-l-menthoxypropane-1,2-diol and intermediates to be used in the method. As shown in the following reaction formula, 3-l-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding l-menthol to a 1,2-epoxy-3-halogenopropane represented by the general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid, thereby producing a 1-halogeno-3-l-menthoxypropan-2-ol represented by the general formula (II), allowing the first intermediate to react with an alkali metal salt of an aliphatic carboxylic acid having from 1 to 5 carbon atoms to produce a 1-acyloxy-2-substituted-3-l-menthoxypropane represented by the general formula (III) and then hydrolyzing the second intermediate.

  一种安全高效地生产高纯度3-叶酚基丙烷-1,2-二醇及其中间体的方法，用于该方法。如下反应方程所示，通过将叶醇加入到一种1,2-环氧-3-卤代丙烷（通式（I）中X代表卤素原子）的有机溶剂中，在Lewis酸的存在下产生3-叶酚基丙烷-1,2-二醇（化学式（IV）），从而产生1-卤代-3-叶酚基丙烷-2-醇（通式（II）），让第一个中间体与具有1至5个碳原子的脂肪族羧酸的碱金属盐发生反应，产生1-酰氧基-2-取代-3-叶酚基丙烷（通式（III）），然后水解第二个中间体。
• PROCESS FOR PRODUCING 3-L-MENTHOXYPROPANE-1,2-DIOL
  申请人：——

  公开号：US20020077367A1

  公开（公告）日：2002-06-20

  A process for producing highly pure 3 -l-menthoxypropane- 1,2 -diol safely and efficiently, and an intermediate to be used in the process. 3 -l-menthoxypropane- 1,2 -diol represented by the chemical formula (IV) is produced by adding l-menthol to a 1,2 -epoxy- 3 -halogenopropane represented by the following general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid to produce a novel 1 -halogeno- 3 -l-menthoxypropan- 2 -ol represented by the following general formula (II), then, epoxidating it with a base in the presence of a phase transfer catalyst to produce a 1,2 -epoxy- 3 -l-menthoxypropane represented by the chemical formula (III), and further hydrolyzing it.

  一种生产高纯3-l-menthoxypropane-1,2-diol的安全高效工艺，以及用于该工艺的中间体。通过在有机溶剂中加入l-menthol到下列通式(I)（其中X代表卤素原子）所代表的1,2-环氧-3-卤代丙烷中，在路易斯酸存在下生成一种新的1-卤代-3-l-menthoxypropan-2-ol，其通式为(II)，然后在相转移催化剂存在下，用碱对其进行环氧化反应，得到3-l-menthoxypropane-1,2-diol的前体1,2-环氧-3-l-menthoxypropane，其化学式为(III)，最后进行水解反应得到3-l-menthoxypropane-1,2-diol，其化学式为(IV)。
• Process for producing 3-l-menthoxypropane-1,2-diol
  申请人：Takasago International Corporation

  公开号：EP1201635A1

  公开（公告）日：2002-05-02

  A process for producing highly pure 3-1-menthoxypropane-1,2-diol safely and efficiently, and an intermediate to be used in the process. 3-1-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding 1-menthol to a 1,2-epoxy-3-halogenopropane represented by the following general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid to produce a novel 1-halogeno-3-1-menthoxypropan-2-ol represented by the following general formula (II), then, epoxidating it with a base in the presence of a phase transfer catalyst to produce a 1,2-epoxy-3-1-menthoxypropane represented by the chemical formula (III), and further hydrolyzing it.

  一种安全高效地生产高纯度 3-1-薄荷氧基丙烷-1,2-二醇的工艺，以及用于该工艺的中间体。在路易斯酸存在下，在有机溶剂中将 1-薄荷醇加入到下式通式（I）（其中 X 代表卤素原子）所代表的 1,2-环氧-3-卤代丙烷中，生成下式通式（II）所代表的新型 1-卤代-3-1-薄荷氧基丙-2-醇，从而制得化学式（IV）所代表的 3-1-薄荷氧基丙烷-1,2-二醇、然后，在相转移催化剂存在下，用碱将其环氧化，生成化学式（III）代表的 1,2-环氧-3-1-薄荷氧基丙烷，并将其进一步水解。
• US6515188B2
  申请人：——

  公开号：US6515188B2

  公开（公告）日：2003-02-04