8-<(6-ketoheptyl)amino>-6-methoxylepidine | 74509-60-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-<(6-ketoheptyl)amino>-6-methoxylepidine
• 英文别名: 8-[6-Ketoheptylamino]-6-methoxylepidine；7-[(6-methoxy-4-methylquinolin-8-yl)amino]heptan-2-one
• CAS: 74509-60-7
• 化学式: C₁₈H₂₄N₂O₂
• 分子量: 300.401
• InChiKey: SIHLDKGTWZGELZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-<(6-ketoheptyl)amino>-6-methoxylepidine 在 platinum on activated charcoal lithium aluminium tetrahydride 、 3 A molecular sieve 、 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 6.0h， 生成 8-<<6-(N-ethyl-N-isopropylamino)heptyl>amino>-6-methoxy-4-methylquinoline
  参考文献：
  名称：

  Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents

  摘要：

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.

  DOI：

  10.1021/jm00183a004
• 作为产物：
  描述：

  6-溴己腈 在 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 8-<(6-ketoheptyl)amino>-6-methoxylepidine
  参考文献：
  名称：

  Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents

  摘要：

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.

  DOI：

  10.1021/jm00183a004

文献信息

• DAGLI D.; KHAN M. S.; BLUMBERGS P., J. MED. CHEM., 1980, 23, NO 9, 981-985
  作者：DAGLI D.、 KHAN M. S.、 BLUMBERGS P.

  DOI：——

  日期：——
• Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents
  作者：Maurice P. LaMontagne、Dinesh Dagli、M. Sami Khan、Peter Blumbergs

  DOI：10.1021/jm00183a004

  日期：1980.9

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.