5-methyl-2-{[4-(propan-2-yl)benzyl]amino}[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5-methyl-2-{[4-(propan-2-yl)benzyl]amino}[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
• 英文别名: 5-methyl-2-[(4-propan-2-ylphenyl)methylamino]-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
• 化学式: C₁₆H₁₉N₅O
• 分子量: 297.35
• InChiKey: AOJBWNCPPWXPRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] PANK MODULATORS AND METHODS USING SAME<br/>[FR] MODULATEURS DE PANK ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV YALE

  公开号：WO2021262786A1

  公开（公告）日：2021-12-30

  The disclosure relates, in certain aspects, to the discovery of certain compounds that are useful to treat and/or prevent fungal infections in a subject. The disclosure further relates, in certain aspects, to the discovery of certain compounds that are useful are useful for treating, ameliorating, and/or preventing diseases or disorders associated with reduced and/or deficient PanK activity in a subject. In certain embodiments, the disease or disorder comprises a neurodegenerative disease, such as but not limited to pantothenate kinaseassociated neurodegeneration (PKAN).