5,5-Dimethyl-dihydro-pyran-2,4-dione | 874097-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 5,5-Dimethyl-dihydro-pyran-2,4-dione
• 英文别名: 2H-Pyran-2,4(3H)-dione, dihydro-5,5-dimethyl-；5,5-dimethyloxane-2,4-dione
• CAS: 874097-49-1
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: BSHMHJKIVNWRTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,5-Dimethyl-dihydro-pyran-2,4-dione 、 3-(三氟甲基)异氰酸苯酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.25h， 以40.4%的产率得到N-[3-(trifluoromethyl)phenyl]-5,5-dimethyl-2,4-dioxotetrahydro-2H-pyran-3-carboxamide
  参考文献：
  名称：

  Dioxocyclohexane carboxylic acid phenyl amide derivatives for modulating voltage-gated potassium channels and pharmaceutical compositions containing the same

  摘要：

  二氧环己烷羧酸苯胺衍生物，其通式为(I)的化合物或其互变异构体或其药学上可接受的盐，以及含有这些化合物的药物组合物被提供：这些二氧环己烷羧酸苯胺衍生物可用于治疗与一个或多个Kv1.1电压门控钾通道异常调节相关的多种病症。

  公开号：

  US20060014826A1
• 作为产物：
  描述：

  3-acetoxy-2,2-dimethyl-propionic acid methyl ester 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.5h， 以58%的产率得到5,5-Dimethyl-dihydro-pyran-2,4-dione
  参考文献：
  名称：

  Dioxocyclohexane carboxylic acid phenyl amide derivatives for modulating voltage-gated potassium channels and pharmaceutical compositions containing the same

  摘要：

  二氧环己烷羧酸苯胺衍生物，其通式为(I)的化合物或其互变异构体或其药学上可接受的盐，以及含有这些化合物的药物组合物被提供：这些二氧环己烷羧酸苯胺衍生物可用于治疗与一个或多个Kv1.1电压门控钾通道异常调节相关的多种病症。

  公开号：

  US20060014826A1

文献信息

• [EN] BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE 1,4-DIHYDROPYRIDINE SUBSTITUÉS PAR INDAZOLE BI- ET TRICYCLIQUES ET LEURS UTILISATIONS
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2010094405A1

  公开（公告）日：2010-08-26

  This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.

  本发明涉及具有蛋白酪氨酸激酶抑制活性的新型双环和三环吲唑取代的1,4-二氢吡啶衍生物，以及其制备方法和用于治疗c-Met介导疾病或c-Met介导病症，特别是癌症和其他增殖性疾病的用途。
• Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof
  申请人：Michels Martin

  公开号：US08759341B2

  公开（公告）日：2014-06-24

  This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.

  本发明涉及一种新型的双环和三环吲哚取代的1,4-二氢吡啶衍生物，具有蛋白酪氨酸激酶抑制活性，以及其制造方法和用于治疗c-Met介导的疾病或c-Met介导的病症，特别是癌症和其他增生性疾病的用途。
• Insecticidal heterolignans—Tubuline polymerization inhibitors with activity against chewing pests
  作者：Jens Frackenpohl、Isabelle Adelt、Horst Antonicek、Christian Arnold、Patricia Behrmann、Nicole Blaha、Jutta Böhmer、Oliver Gutbrod、Roman Hanke、Sabine Hohmann、Marc van Houtdreve、Peter Lösel、Olga Malsam、Martin Melchers、Valentina Neufert、Elisabeth Peschel、Udo Reckmann、Thomas Schenke、Hans-Peter Thiesen、Robert Velten、Kathrin Vogelsang、Hans-Christoph Weiss

  DOI：10.1016/j.bmc.2009.01.042

  日期：2009.6

  Starting from natural product podophyllotoxin 1 substituted heterolignans were identified with promising insecticidal in vivo activity. The impact of substitution in each segment of the core structure was investigated in a detailed SAR study, and variation of substituents in both aromatic moieties afforded derivatives 5 and 43 with broad insecticidal activity against lepidopteran and coleopteran species. In vitro measurements supported by modeling studies indicate that heterolignans 3-134 act as tubuline polymerization inhibitors interacting with the colchicine-binding site. Insect specific structure-activity effects were observed showing that the insecticidal SAR described herein differs from reported cytotoxicity studies. (C) 2009 Elsevier Ltd. All rights reserved.
• BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF
  申请人：Bayer Intellectual Property GmbH

  公开号：EP2398790B1

  公开（公告）日：2013-07-03
• US8759341B2
  申请人：——

  公开号：US8759341B2

  公开（公告）日：2014-06-24