(S)-5-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)pentyl 4-methylpiperazine-1-carbodithioate | 1227458-17-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (S)-5-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)pentyl 4-methylpiperazine-1-carbodithioate
• 英文别名: 4-[(11aS)-7-(methyloxy)-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl]oxypentyl 4-methylhexahydro-1-pyrazinecarbodithioate；5-[(11aS)-7-(methyloxy)-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl]oxypentyl 4-methylhexahydro-1-pyrazinecarbodithioate；5-[[(6aS)-2-methoxy-11-oxo-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]pentyl 4-methylpiperazine-1-carbodithioate
• CAS: 1227458-17-4
• 化学式: C₂₄H₃₄N₄O₃S₂
• 分子量: 490.691
• InChiKey: NYHSMCDTWYWATO-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (2S)-N-[4-(5-bromopentyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 在 potassium phosphate 、 tin(II) chloride dihdyrate 、 calcium carbonate 、 mercury dichloride 作用下， 以 甲醇 、 水 、 丙酮 、 乙腈 为溶剂， 反应 18.0h， 生成 (S)-5-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)pentyl 4-methylpiperazine-1-carbodithioate
  参考文献：
  名称：

  NOVEL PYRROLO[2,1-C][1,4] BENZODIAZEPINE DERIVATIVES WITH DITHIOCARBAMATE SIDE CHAINS AND PROCESS FOR THE PREPARATION THEREOF

  摘要：

  本发明提供了一种合成和体外抗癌活性的新型噻唑并[2,1-c][1,4]苯并二氮杂环衍生物，其具有二硫代氨基甲酸酯侧链。本发明还涉及一种制备具有一般式(A)的新型噻唑并[2,1-c][1,4]苯并二氮杂环衍生物及其制备方法。

  公开号：

  US20120101270A1

文献信息

• NOVEL PYRROLO[2,1-C][1,4] BENZODIAZEPINE DERIVATIVES WITH DITHIOCARBAMATE SIDE CHAINS AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Ahmed Kamal

  公开号：US20120101270A1

  公开（公告）日：2012-04-26

  The present invention provides synthesis and in vitro anticancer activity of novel pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains. The present invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains of general formula (A) and a process for the preparation thereof.

  本发明提供了一种合成和体外抗癌活性的新型噻唑并[2,1-c][1,4]苯并二氮杂环衍生物，其具有二硫代氨基甲酸酯侧链。本发明还涉及一种制备具有一般式(A)的新型噻唑并[2,1-c][1,4]苯并二氮杂环衍生物及其制备方法。
• [EN] NOVEL PYRROIOL2,L-CU1.41BENZODIAZEPINE DERIVATIVES WITH DITHIOCARBAMATE SIDE CHAINS AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRROLO[2,1-C][1,4]BENZODIAZÉPINE POSSÉDANT DES CHAÎNES LATÉRALES DITHIOCARBAMATE ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2010058414A1

  公开（公告）日：2010-05-27

  The present invention provides synthesis and in vitro anticancer activity of novel pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains. The present invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains of general formula (A) and a process for the preparation thereof.

  本发明提供了一种合成和体外抗癌活性的新型噻唑[2,1-c][1,4]苯并二氮杂环衍生物，其具有硫代氨基甲酸酯侧链。本发明还涉及一种用于制备具有硫代氨基甲酸酯侧链的新型噻唑[2,1-c][1,4]苯并二氮杂环衍生物的方法，该方法的一般公式为（A），以及其制备方法。
• Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: Synthesis, DNA-binding affinity and cytotoxic activity
  作者：Ahmed Kamal、Kokkonda Sreekanth、Nagula Shankaraiah、Manda Sathish、Shalini Nekkanti、Vunnam Srinivasulu

  DOI：10.1016/j.bioorg.2015.01.002

  日期：2015.4

  A new series of C8-linked dithiocarbamate/piperazine bridged pyrrolo[2,1-c][1,4] benzodiazepine conjugates (5a-c, 6a, b) have been synthesized and evaluated for their cytotoxic potential and DNA-binding ability. The representative conjugates 5a and 5b have been screened for their cytotoxicity against a panel of 60 human cancer cell lines. Compound 5a has shown promising cytotoxic activity on selected cancer cell lines that display melanoma, leukemia, CNS, ovarian, breast and renal cancer phenotypes. The consequence of further replacement of the 3-cyano-3,3-diphenylpropyl 1-piperazinecarbodithioate in 5b and 5c with 4-methylpiperazine-1-carbodithioate yielded new conjugates 6a and 6b respectively. In addition, the compounds 5c and 6a, b have been evaluated for their in vitro cytotoxicity on some of the selected human cancer cell lines and these conjugates have exhibited significant cytotoxic activity. Further, the DNA-binding ability of these new conjugates has been evaluated by using thermal denaturation (Delta T-m) studies. The correlation between structure and DNA-binding ability has been investigated by molecular modeling studies which predicted that 6b exhibits superior DNA-binding ability and these are in agreement with the experimental DNA-binding studies. (C) 2015 Elsevier Inc. All rights reserved.