2,2-dioxo-N'-(4-propan-2-ylbenzoyl)-3,4-dihydro-1H-pyrido[2,1-c][1,2,4]thiadiazin-5-ium-9-carbohydrazide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,2-dioxo-N'-(4-propan-2-ylbenzoyl)-3,4-dihydro-1H-pyrido[2,1-c][1,2,4]thiadiazin-5-ium-9-carbohydrazide
• 化学式: C18H21N4O4S+
• 分子量: 389.5
• InChiKey: GCRHEPSMACGAKB-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• HETEROCYCLIC COMPOUND AND USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20200317692A1

  公开（公告）日：2020-10-08

  Provided is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, which has an AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor potentiating action. The compound of the present invention is useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease or attention deficit hyperactivity disorder (ADHD) and the like.