4,5,5a,6-tetrahydro-3H-isoxazolo<5,4,3-kl>acridine-6-carbonyl chloride | 129578-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4,5,5a,6-tetrahydro-3H-isoxazolo<5,4,3-kl>acridine-6-carbonyl chloride
• 英文别名: 4,5,5a,6-tetrahydro-3H-isoxazolo[5,4,3-kl]acridine-6-carbonyl chloride；4,5,5a,6-Tetrahydro-3H-isoxazolo[5,4,3-kl]acridine-6-cabonyl chloride；14-oxa-8,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,13(16)-pentaene-8-carbonyl chloride
• CAS: 129578-56-9
• 化学式: C₁₄H₁₁ClN₂O₂
• 分子量: 274.707
• InChiKey: WTGIPGPJPNDJHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-氨基乙基)吗啉 、 4,5,5a,6-tetrahydro-3H-isoxazolo<5,4,3-kl>acridine-6-carbonyl chloride 以 四氯化碳 为溶剂， 反应 2.0h， 以67%的产率得到N-<2-(4-morpholino)ethyl>-4,5,5a,6-tetrahydro-3H-isoxazolo<5,4,3-kl>acridine-6-carboxamide
  参考文献：
  名称：

  Shutske, Gregory M., Journal of Heterocyclic Chemistry, 1990, vol. 27, # 6, p. 1617 - 1621

  摘要：

  DOI：
• 作为产物：
  描述：

  4,5-dihydro-3H-isoxazolo<5,4,3-kl>acridine 在 sodium cyanoborohydride 、 三乙胺 作用下， 以 二氯甲烷 、 溶剂黄146 、 苯 为溶剂， 反应 1.0h， 生成 4,5,5a,6-tetrahydro-3H-isoxazolo<5,4,3-kl>acridine-6-carbonyl chloride
  参考文献：
  名称：

  Shutske, Gregory M., Journal of Heterocyclic Chemistry, 1990, vol. 27, # 6, p. 1617 - 1621

  摘要：

  DOI：

文献信息

• 4,5,5a,6-tetrahydro-3H-isoxazolo(5,4,3-kl)acridines, pharmaceutical
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04920117A1

  公开（公告）日：1990-04-24

  There are disclosed compounds having the formula ##STR1## where X is hydrogen, loweralkyl, loweralkoxy, halogen or trifluoromethyl, and R when present is hydrogen, loweralkyl, allyl, arylloweralkyl, ##STR2## wherein R.sub.1 is loweralkyl, --CH.sub.2 C.tbd.CH, ##STR3## n being 2, 3 or 4 and R.sub.2 and R.sub.3 being independently loweralkyl, or the group ##STR4## taken as a whole constituting ##STR5## which compounds are useful as analgesic agents and also for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease.

  公开了具有以下结构式的化合物：##STR1## 其中X是氢，低碳基，低碳氧基，卤素或三氟甲基，当存在R时，R是氢，低碳基，烯丙基，芳基低碳基，##STR2##其中R.sub.1是低碳基，--CH.sub.2 C.tbd.CH，##STR3##其中n为2、3或4，R.sub.2和R.sub.3独立地为低碳基，或作为整体构成##STR4##的基团，这些化合物可用作镇痛剂，并用于治疗各种记忆功能障碍，其特征是胆碱能功能降低，如阿尔茨海默病。
• Method of preparing isoxazolo(5,4,3-kl)acridines
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04942237A1

  公开（公告）日：1990-07-17

  There are disclosed compounds having the formula ##STR1## where X is hydrogen, loweralkyl, loweralkoxy, halogen or trifluoromethyl, and R when present is hydrogen, loweralkyl, allyl, arylloweralkyl, ##STR2## wherein R.sub.1 is loweralkyl, --CH.sub.2 C.tbd.CH, ##STR3## n being 2, 3 or 4 and R.sub.2 and R.sub.3 being independently loweralkyl, or the group ##STR4## taken as a whole constituting ##STR5## which compounds are useful as analgesic agents and also for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease.

  公开了具有以下式子的化合物##STR1## 其中X为氢、低烷基、低烷氧基、卤素或三氟甲基，R在存在时为氢、低烷基、烯丙基、芳基低烷基、##STR2##其中R.sub.1为低烷基、--CH.sub.2 C.tbd.CH、##STR3##n为2、3或4，R.sub.2和R.sub.3独立地为低烷基，或者作为整体构成##STR4##这些化合物可用作镇痛剂，并用于治疗各种记忆功能障碍，其特征是乙酰胆碱能功能降低，例如阿尔茨海默病。
• 4,5,5a,6-Tetrahydro-3H-isoxazolo (5,4,3-kl)acridines derivatives, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0401779A1

  公开（公告）日：1990-12-12

  There are disclosed compounds having the formula where X is hydrogen, loweralkyl, loweralkoxy, halogen or trifluoromethyl, and R when present is hydrogen, loweralkyl, allyl, arylloweralkyl, wherein R1 is loweralkyl, n being 2, 3 or 4 and R2 and R3 being independently loweralkyl, or the group taken as a whole constituting which compounds are useful as analgesic agents and also for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease.

  已公开的化合物具有如下式子 式中 X为氢、低级烷基、低级烷氧基、卤素或三氟甲基，R为氢、低级烷基、烯丙基、芳基低级烷基、 其中 R1 为低级烷基、 n 为 2、3 或 4，R2 和 R3 独立地为低级烷基，或该基团 整体构成 这些化合物可用作镇痛剂，也可用于治疗以胆碱能功能减退为特征的各种记忆功能障碍，如阿尔茨海默氏症。
• SHUTSKE, GREGORY M.
  作者：SHUTSKE, GREGORY M.

  DOI：——

  日期：——
• US4920117A
  申请人：——

  公开号：US4920117A

  公开（公告）日：1990-04-24