[1,1-Dichloro-5-(2-methyl-1,3-dioxolan-2-yl)pent-1-en-3-yl]-trimethylsilane | 1167443-90-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [1,1-Dichloro-5-(2-methyl-1,3-dioxolan-2-yl)pent-1-en-3-yl]-trimethylsilane
• 英文别名: [1,1-dichloro-5-(2-methyl-1,3-dioxolan-2-yl)pent-1-en-3-yl]-trimethylsilane
• CAS: 1167443-90-4
• 化学式: C₁₂H₂₂Cl₂O₂Si
• 分子量: 297.297
• InChiKey: YHFZYWBLKIPOOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.56
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [1,1-Dichloro-5-(2-methyl-1,3-dioxolan-2-yl)pent-1-en-3-yl]-trimethylsilane 、 环己酮 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以63%的产率得到1-[5-(2-Methyl-1,3-dioxolan-2-yl)-3-trimethylsilylpent-1-ynyl]cyclohexan-1-ol
  参考文献：
  名称：

  A Flexible Radical-Based Approach to TMS-Substituted Propargyl Alcohols and to 2,3-Allenols

  摘要：

  The radical reaction of TMS-substituted xanthates with 2,2-dichlorovinyl ethyl sulfone afforded TMS-substituted homodichlorovinyl compounds that can be transformed into TMS-substituted propargyl alcohols. Various 2,3-allenols were efficiently prepared from the reaction of these TMS-substituted propargyl alcohols with TBAF.

  DOI：

  10.1021/ol900739x
• 作为产物：
  描述：

  7,7-Dichloro-5-trimethylsilylhept-6-en-2-one 、 乙二醇 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以84%的产率得到[1,1-Dichloro-5-(2-methyl-1,3-dioxolan-2-yl)pent-1-en-3-yl]-trimethylsilane
  参考文献：
  名称：

  A Flexible Radical-Based Approach to TMS-Substituted Propargyl Alcohols and to 2,3-Allenols

  摘要：

  The radical reaction of TMS-substituted xanthates with 2,2-dichlorovinyl ethyl sulfone afforded TMS-substituted homodichlorovinyl compounds that can be transformed into TMS-substituted propargyl alcohols. Various 2,3-allenols were efficiently prepared from the reaction of these TMS-substituted propargyl alcohols with TBAF.

  DOI：

  10.1021/ol900739x

文献信息

• A Flexible Radical-Based Approach to TMS-Substituted Propargyl Alcohols and to 2,3-Allenols
  作者：Zhi Li、Samir Z. Zard

  DOI：10.1021/ol900739x

  日期：2009.7.2

  The radical reaction of TMS-substituted xanthates with 2,2-dichlorovinyl ethyl sulfone afforded TMS-substituted homodichlorovinyl compounds that can be transformed into TMS-substituted propargyl alcohols. Various 2,3-allenols were efficiently prepared from the reaction of these TMS-substituted propargyl alcohols with TBAF.