(E)-tert-butyl 2-phenyl-5-styryloxazole-4-carboxylate | 1225057-31-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (E)-tert-butyl 2-phenyl-5-styryloxazole-4-carboxylate
• 英文别名: tert-butyl 2-phenyl-5-[(E)-2-phenylethenyl]-1,3-oxazole-4-carboxylate
• CAS: 1225057-31-7
• 化学式: C₂₂H₂₁NO₃
• 分子量: 347.414
• InChiKey: QOLKLSFMMQBFJM-CCEZHUSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-tert-butyl 3-oxo-5-phenylpent-4-enoate 、 苄胺 在 叔丁基过氧化氢 、 碘 、 copper(II) acetate monohydrate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以78%的产率得到(E)-tert-butyl 2-phenyl-5-styryloxazole-4-carboxylate
  参考文献：
  名称：

  Facile Synthesis of Polysubstituted Oxazoles via A Copper-Catalyzed Tandem Oxidative Cyclization

  摘要：

  A highly efficient synthesis of polysubstituted oxazoles was developed via a copper-catalyzed tandem oxidative cyclization. The desired products can be obtained from readily available starting materials under mild conditions. This is an attractive alternative method for the synthesis of oxazole derivatives.

  DOI：

  10.1021/ol100688c

文献信息

• Facile Synthesis of Polysubstituted Oxazoles via A Copper-Catalyzed Tandem Oxidative Cyclization
  作者：Changfeng Wan、Jintang Zhang、Sujing Wang、Jinmin Fan、Zhiyong Wang

  DOI：10.1021/ol100688c

  日期：2010.5.21

  A highly efficient synthesis of polysubstituted oxazoles was developed via a copper-catalyzed tandem oxidative cyclization. The desired products can be obtained from readily available starting materials under mild conditions. This is an attractive alternative method for the synthesis of oxazole derivatives.