1,1,1-trifluoro-3-(2-quinolyl)-2-propanone | 398-50-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,1,1-trifluoro-3-(2-quinolyl)-2-propanone
• 英文别名: 1,1,1-trifluoro-3-quinolin-2-yl-propan-2-one；1,1,1-Trifluoro-3-(quinolin-2-yl)propan-2-one；1,1,1-trifluoro-3-quinolin-2-ylpropan-2-one
• CAS: 398-50-5
• 化学式: C₁₂H₈F₃NO
• mdl: MFCD00487349
• 分子量: 239.197
• InChiKey: LVPPHTPGIQXDGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲基喹啉 、 三氟乙酸酐 在 吡啶 作用下， 以57%的产率得到1,1,1-trifluoro-3-(2-quinolyl)-2-propanone
  参考文献：
  名称：

  Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections

  摘要：

  We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas' disease. Furthermore, several quinolines have also been tested for their anti-retroviral activity in HIV-1 infected cells. The structure activity relationships of these new synthetic compounds are discussed and emphasis was placed on the treatment of leishmania/HIV co-infections. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.09.007

文献信息

• Trifluoroacetylation of Methylpyridines and Other Methylazines: A Convenient Access to Trifluoroacetonylazines
  作者：Masami Kawase、Mutsumi Teshima、Setsuo Saito、Satoru Tani

  DOI：10.3987/com-98-8268

  日期：——

  Treatment of methyl substituted azines, such as pyridine, pyrimidine, quinoline, oxazole, benzoxazole, benzimidazole, and benzothiazole, with trifluoroacetic anhydride in the presence of pyridine at room temperature gave the corresponding trifluoroacetonyl substituted azines in good yields.