(5E,7E)-6-methyl-4-methylidene-8-(2,6,6-trimethylcyclohexen-1-yl)octa-5,7-dien-1-amine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (5E,7E)-6-methyl-4-methylidene-8-(2,6,6-trimethylcyclohexen-1-yl)octa-5,7-dien-1-amine
• 化学式: C₁₉H₃₁N
• 分子量: 273.5
• InChiKey: LAYQVMWXDWHFAD-OIPGSKEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] METHODS FOR THE TREATMENT OF DIABETIC RETINOPATHY AND OTHER OPHTHALMIC DISEASES<br/>[FR] PROCÉDÉS POUR LE TRAITEMENT DE LA RÉTINOPATHIE DIABÉTIQUE ET D'AUTRES MALADIES OPHTALMIQUES
  申请人：ACUCELA INC

  公开号：WO2013166449A2

  公开（公告）日：2013-11-07

  Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
• [EN] PUPILLOMETRIC ASSESSMENT OF RETINAL PHARMACODYNAMICS AND RESPONSES THEREFROM<br/>[FR] EVALUATION PUPILLOMÉTRIQUE DE PHARMACODYNAMIES RÉTINIENNES ET RÉACTIONS CORRESPONDANTES
  申请人：ACUCELA INC

  公开号：WO2015164419A1

  公开（公告）日：2015-10-29

  Disclosed herein are methods of predicting a subject's response to a visual cycle modulator, methods of diagnosing a subject susceptible to an ocular disease or disorder, methods of guiding dose selection of a visual cycle modulator, methods of treating an ocular disease, and systems for measuring pupillary light response (PLR).