trithiocarbonic acid monohexyl ester | 92919-23-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trithiocarbonic acid monohexyl ester
• 英文别名: Trithiokohlensaeure-monohexylester；Hexyl-trithiokohlensaeure；Hexylsulfanylmethanedithioic acid
• CAS: 92919-23-8
• 化学式: C₇H₁₄S₃
• 分子量: 194.386
• InChiKey: DEMYCXXAQKCRNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  trithiocarbonic acid monohexyl ester 在 氯化苄 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 18.0h， 生成 S-benzyl-S'-hexyl-trithiocarbonate
  参考文献：
  名称：

  Efficient Production of Block-copolymer-coated Ceramic Nanoparticles by Sequential Reversible Addition–Fragmentation Chain-transfer Polymerizations with Particles (SqRAFTwP)

  摘要：

  陶瓷纳米粒子（NPs）通过原位合成的嵌段共聚物进行表面改性并分散。通过连续添加单体进行活化自由基聚合，使嵌段共聚物能够有效地包裹陶瓷纳米粒子。这种方法使我们能够在任何类型的纳米粒子上添加稳定的聚合物层；因此，它有助于大规模生产聚合物包覆的无机纳米粒子，并大幅降低成本，同时不会影响其性能。

  DOI：

  10.1246/cl.130272
• 作为产物：
  描述：

  二硫化碳 、 1-己硫醇 在 sodium methylate 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 5.0h， 生成 trithiocarbonic acid monohexyl ester
  参考文献：
  名称：

  Efficient Production of Block-copolymer-coated Ceramic Nanoparticles by Sequential Reversible Addition–Fragmentation Chain-transfer Polymerizations with Particles (SqRAFTwP)

  摘要：

  陶瓷纳米粒子（NPs）通过原位合成的嵌段共聚物进行表面改性并分散。通过连续添加单体进行活化自由基聚合，使嵌段共聚物能够有效地包裹陶瓷纳米粒子。这种方法使我们能够在任何类型的纳米粒子上添加稳定的聚合物层；因此，它有助于大规模生产聚合物包覆的无机纳米粒子，并大幅降低成本，同时不会影响其性能。

  DOI：

  10.1246/cl.130272

文献信息

• MEDICAL DEVICES HAVING HOMOGENEOUS CHARGE DENSITY AND METHODS FOR MAKING SAME
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20130203813A1

  公开（公告）日：2013-08-08

  The present invention relates to ionic silicone hydrogel polymers comprising at least one pharmaceutical or nutriceutical component and displaying improved lysozyme uptake, low contact angle and reduced water soluble polymeric ammonium salt uptake.

  本发明涉及离子硅氢凝胶聚合物，其中包含至少一种药物或营养成分，并具有改进的溶菌酶摄取、低接触角和减少的可溶性聚合物铵盐摄取。
• 4-ACYLAMINOPYRAZOLE DERIVATIVES
  申请人：Sankyo Company, Limited

  公开号：EP1329160A2

  公开（公告）日：2003-07-23

  A 4-acylaminopyrazole derivative represented by the following general formula: wherein R1 is a hydrogen atom, an optionally substituted C1-C16 alkyl group or the like,    R2 and R3 are independently a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group or the like, R4 is a hydrogen atom, a C1-C6 alkyl group or a cyano group, Z is an oxygen atom or a sulfur atom, Ar is an optionally substituted C6-C14 aryl group or an optionally substituted 5-6 membered unsaturated heterocyclic group, B is a hydrogen atom, a halogen atom, an optionally substituted C1-C16 alkyl group or the like.

  由以下通式代表的 4-酰氨基吡唑衍生物： 其中 R1 是氢原子、任选取代的 C1-C16 烷基或类似基团、 R2 和 R3 独立地为氢原子、卤素原子、任选取代的 C1-C6 烷基或类似基团、 R4 是氢原子、C1-C6 烷基或氰基、 Z 是氧原子或硫原子、 Ar 是任选取代的 C6-C14 芳基或任选取代的 5-6 位元不饱和杂环基团、 B 是氢原子、卤素原子、任选取代的 C1-C16 烷基或类似基团。
• Polymers and nanogel materials and methods for making and using the same
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US10073192B2

  公开（公告）日：2018-09-11

  Provided are compositions comprising a block copolymer of the following formula: [A]-B-[Q], wherein [A] is a polymer that has an affinity for a substrate; B is a linking group comprising an optionally-substituted, polyvalent linking group having a molecular weight of no more than 1000 g/mole; and [Q] comprises a semi-crosslinked, ungelled polymer derived from copolymerization of an ethylenically unsaturated monomer with a poly-functional ethylenically unsaturated monomer. Such block copolymers are cross-linked via the [Q] segment, but not macroscopically gelled. The [Q] segment is hydrophilic and has a degree of polymerization in the range of about 10 to about 10,000. The [A] segment is located on at least one terminal end of said block copolymer, comprises between about 1 and about 200 repeating units. The block copolymer is associated, via the linear substrate associative segment with a surface comprising at least one hydrophobic site, such as a silicone hydrogel. The polymers may be incorporated into a formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post-formation.

  本发明提供了包含下式嵌段共聚物的组合物：[A]-B-[Q]，其中[A]是对底物具有亲和力的聚合物；B 是由任选取代的多价连接基团组成的连接基团，其分子量不超过 1000 克/摩尔；[Q]是由乙烯基不饱和单体与多官能团乙烯基不饱和单体共聚而成的半交联、未胶凝的聚合物。这种嵌段共聚物通过[Q]段交联，但宏观上并不胶凝。Q]段具有亲水性，聚合度在约 10 到约 10,000 之间。A]段位于所述嵌段共聚物的至少一个末端，包含约 1 至约 200 个重复单元。嵌段共聚物通过线性基质连接段与包含至少一个疏水位点的表面（如硅酮水凝胶）连接。聚合物可以加入硅酮水凝胶的配方中，也可以在成型后与硅酮水凝胶接触。
• Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US10301465B2

  公开（公告）日：2019-05-28

  The present invention relates to compositions comprising at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer's backbone, a hydrophilic segment having a degree of polymerization of about 10 to about 1000, and a linear silicone segment at at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, and said non-reactive hydrophilic polymer is associated, via the linear silicone block with a silicone hydrogel. The non-reactive hydrophilic polymers may be incorporated into the formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post formation.

  本发明涉及包含至少一种稳定的、接近单分散的、非反应性亲水聚合物的组合物，所述聚合物的骨架中包含聚合度约为10至约1000的亲水段，以及位于所述非反应性亲水聚合物至少一个末端的线性硅酮段，其中所述硅酮段包含约6至约200个硅氧基单元，所述非反应性亲水聚合物通过线性硅酮块与硅酮水凝胶相连。非反应性亲水聚合物可以加入硅酮水凝胶的配方中，也可以在硅酮水凝胶形成后与之接触。
• Medical devices having homogeneous charge density and methods for making same
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US11067720B2

  公开（公告）日：2021-07-20

  The present invention relates to ionic silicone hydrogel polymers displaying improved lysozyme uptake, low contact angle and reduced water soluble polymeric ammonium salt uptake.

  本发明涉及离子型硅酮水凝胶聚合物，该聚合物可提高溶菌酶吸收率、降低接触角并减少水溶性聚合铵盐的吸收。