1-phenyl-3-p-tolylquinolin-4(1H)-one | 1258792-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-phenyl-3-p-tolylquinolin-4(1H)-one
• 英文别名: 3-(4-Methylphenyl)-1-phenylquinolin-4-one；3-(4-methylphenyl)-1-phenylquinolin-4-one
• CAS: 1258792-53-8
• 化学式: C₂₂H₁₇NO
• 分子量: 311.383
• InChiKey: BHPYUBRJDONEIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-Bromophenyl)-2-(4-methylphenyl)ethanone 在 三氯氧磷 作用下， 以 二甲基亚砜 为溶剂， 反应 8.5h， 生成 1-phenyl-3-p-tolylquinolin-4(1H)-one
  参考文献：
  名称：

  Metal-Free Intramolecular Amination: One-Pot Tandem Synthesis of 3-Substituted 4-Quinolones

  摘要：

  3-Substituted 4-quinolones were synthesized using a one-pot metal-free strategy in moderate to quantitative yields. Carried out in dimethylsulfoxide (DMSO) via a sequential addition of materials, the methodology is tolerant of a wide range of functional groups and applicable to library synthesis.

  DOI：

  10.1021/co1000103

文献信息

• Metal-Free Intramolecular Amination: One-Pot Tandem Synthesis of 3-Substituted 4-Quinolones
  作者：Qi-Lun Liu、Qiu-Lian Li、Xiang-Dong Fei、Yong-Ming Zhu

  DOI：10.1021/co1000103

  日期：2011.1.10

  3-Substituted 4-quinolones were synthesized using a one-pot metal-free strategy in moderate to quantitative yields. Carried out in dimethylsulfoxide (DMSO) via a sequential addition of materials, the methodology is tolerant of a wide range of functional groups and applicable to library synthesis.