1-(4-bromophenyl)-2-fluoro-2-(phenylsulfonyl)ethanone | 1151549-55-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-bromophenyl)-2-fluoro-2-(phenylsulfonyl)ethanone
• 英文别名: 2-(Benzenesulfonyl)-1-(4-bromophenyl)-2-fluoroethanone
• CAS: 1151549-55-1
• 化学式: C₁₄H₁₀BrFO₃S
• 分子量: 357.2
• InChiKey: WCTYGBGZORNCME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对溴苯甲酸甲酯 、 氟甲基苯基砜 在 lithium hexamethyldisilazane 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以92%的产率得到1-(4-bromophenyl)-2-fluoro-2-(phenylsulfonyl)ethanone
  参考文献：
  名称：

  Synthesis of Fluorinated β-Ketosulfones and gem-Disulfones by Nucleophilic Fluoroalkylation of Esters and Sulfinates with Di- and Monofluoromethyl Sulfones

  摘要：

  An efficient and practically useful method for the preparation of alpha-functionalized mono- and difluoro(phenylsulfonyl)methanes by using a nucleophilic fluoroalkylation methodology was developed. alpha,alpha-Difluoro-P-ketosulfones, alpha-monofluoro-beta-ketosulfones, and alpha-fluoro disulfones were successfully prepared in excellent yields by nucleophilic fluoroalkylation of esters and sulfinates with PhSO2CF2H and PhSO2CH2F reagents.

  DOI：

  10.1021/jo900320b

文献信息

• Synthesis of Fluorinated β-Ketosulfones and <i>gem</i>-Disulfones by Nucleophilic Fluoroalkylation of Esters and Sulfinates with Di- and Monofluoromethyl Sulfones
  作者：Chuanfa Ni、Laijun Zhang、Jinbo Hu

  DOI：10.1021/jo900320b

  日期：2009.5.15

  An efficient and practically useful method for the preparation of alpha-functionalized mono- and difluoro(phenylsulfonyl)methanes by using a nucleophilic fluoroalkylation methodology was developed. alpha,alpha-Difluoro-P-ketosulfones, alpha-monofluoro-beta-ketosulfones, and alpha-fluoro disulfones were successfully prepared in excellent yields by nucleophilic fluoroalkylation of esters and sulfinates with PhSO2CF2H and PhSO2CH2F reagents.